Markovskaia E I, Makarovskaia L N, Ryzhkova V V, Zurabian V A
Antibiot Khimioter. 1993 Jul;38(7):37-9.
The therapeutic effect of azlocillin and its combinations with other antibiotics was studied in a model of experimental plague of albino mice. Azlocillin was shown to be efficient in the prophylaxis and treatment of the experimental plague infection. The optimal doses of azlocillin were determined. The protective action of the drug depended on the dose and the time of its administration. The therapeutic effect was mainly defined by the antibiotic dose. The use of azlocillin in not sufficiently active doses in combination with aminoglycosides (gentamicin, sisomicin and amikacin), rifampicin or doxycycline significantly increased the percentage of the animal survival by comparison with that after the use of every antibiotic alone. A synergistic effect was observed when azlocillin was used in combination with rifampicin or amikacin.
在白化小鼠实验性鼠疫模型中研究了阿洛西林及其与其他抗生素联合使用的治疗效果。结果表明，阿洛西林在预防和治疗实验性鼠疫感染方面是有效的。确定了阿洛西林的最佳剂量。该药物的保护作用取决于剂量及其给药时间。治疗效果主要由抗生素剂量决定。与单独使用每种抗生素相比，以活性不足的剂量将阿洛西林与氨基糖苷类（庆大霉素、西索米星和阿米卡星）、利福平或多西环素联合使用，显著提高了动物存活率。当阿洛西林与利福平或阿米卡星联合使用时，观察到协同作用。
