Shcherbaniuk A I, Kasatkina I V, Ryzhko I V
Antibiot Khimioter. 1994 May;39(5):38-40.
The efficacy of combinations of fluoroquinolones (ciprofloxacin and pefloxacin) with betalactams (ampicillin, azlocillin and cefotaxime), aminoglycosides (amikacin) and rifampicin was studied on albino mice infected subcutaneously with plague. The drugs were used in deliberately ineffective or insufficiently effective doses. Synergism was observes with the use of ciprofloxacin and pefloxacin in combinations with amikacin, cefotaxime or rifampicin. The combinations of ciprofloxacin with ampicillin or azlocillin had no synergistic action though the therapeutic effect was not lower. With using the specifically determined doses the efficacy of the combinations could be increased by comparison with that of the drugs used alone.
研究了氟喹诺酮类药物（环丙沙星和培氟沙星）与β-内酰胺类药物（氨苄西林、阿洛西林和头孢噻肟）、氨基糖苷类药物（阿米卡星）以及利福平联合使用对白化小鼠皮下感染鼠疫的疗效。所使用的药物剂量是故意无效或效果欠佳的。观察到环丙沙星和培氟沙星与阿米卡星、头孢噻肟或利福平联合使用时有协同作用。环丙沙星与氨苄西林或阿洛西林联合使用虽无协同作用，但治疗效果并不更低。使用特定确定剂量时，与单独使用药物相比，联合用药的疗效可提高。
