Department of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Ratchatawee, Bangkok, Thailand.
Gynecol Endocrinol. 2009 Aug;25(8):536-42. doi: 10.1080/09513590903015478.
To determine serum visfatin levels in Asian polycystic ovary syndrome (PCOS) women and its correlations with various parameters.
Case-control study.
University hospital.
Eighty women were enrolled in this study. Of these, 40 women were PCOS and 40 age-matched subjects with regular menstrual cycles were controls.
Seventy-five gram oral glucose tolerance tests were performed in all women. Fasting venous blood samples for serum visfatin, insulin and androgen levels were obtained both from the PCOS and the control women.
Serum concentrations of visfatin, fasting insulin (FI), fasting glucose, 2-h post-load glucose (2hPG), homeostasis model assessment insulin resistance, homeostasis model assessment beta cell function, total testosterone, free testosterone, androstenedione and dehydroepiandrosterone sulfate were measured in both groups.
Women with PCOS had significantly higher serum visfatin levels than the healthy controls [100.39 +/- 41.90 vs. 45.09 +/- 28.24 mg/ml, p < 0.01]. PCOS women also had significantly higher concentrations of all androgens (p < 0.01). Insulin resistance seemed to be greater in the PCOS than the control groups, but did not reach a statistically significant level. In the PCOS group, serum visfatin levels were positively correlated with 2hPG, and systolic blood pressure and diastolic blood pressure. Serum visfatin levels were negatively associated with FI (r = -0.80, p = 0.03) and positively associated with systolic and diastolic blood pressure (r = 0.77, p = 0.04, r = 0.79, p = 0.03, respectively) in the sub-group of PCOS women with abnormal glucose tolerance (AGT).
Asian PCOS women had significantly higher serum visfatin levels than age-matched healthy controls. Their levels were significantly correlated with 2hPG and blood pressure in PCOS women, and with FI and blood pressure in PCOS women with AGT.
测定亚洲多囊卵巢综合征（PCOS）妇女血清内脂素水平及其与各参数的相关性。
病例对照研究。
大学医院。
本研究共纳入 80 名女性。其中 40 名 PCOS 患者，40 名年龄匹配的月经周期正常的妇女作为对照组。
所有妇女均行 75g 口服葡萄糖耐量试验。采集 PCOS 妇女和对照组妇女空腹静脉血样，检测血清内脂素、胰岛素和雄激素水平。
两组均检测血清内脂素、空腹胰岛素（FI）、空腹血糖、餐后 2 小时血糖（2hPG）、稳态模型评估胰岛素抵抗指数（HOMA-IR）、稳态模型评估胰岛β细胞功能指数（HOMA-β）、总睾酮、游离睾酮、雄烯二酮和硫酸脱氢表雄酮。
PCOS 妇女血清内脂素水平显著高于健康对照组[（100.39±41.90）mg/ml 比（45.09±28.24）mg/ml，p<0.01]。PCOS 妇女的所有雄激素浓度均显著升高（p<0.01）。PCOS 组胰岛素抵抗似乎高于对照组，但未达到统计学显著水平。在 PCOS 组中，血清内脂素水平与 2hPG 及收缩压和舒张压呈正相关。在葡萄糖耐量异常（AGT）的 PCOS 亚组中，血清内脂素水平与 FI（r=-0.80，p=0.03）呈负相关，与收缩压和舒张压（r=0.77，p=0.04；r=0.79，p=0.03）呈正相关。
亚洲 PCOS 妇女血清内脂素水平显著高于年龄匹配的健康对照组。其水平与 PCOS 妇女的 2hPG 和血压显著相关，与 AGT 的 PCOS 妇女的 FI 和血压显著相关。
