Ikediobi O N, Shin J, Nussbaum R L, Phillips K A, Walsh J M, Ladabaum U, Marshall D
Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, California, USA.
Clin Pharmacol Ther. 2009 Jul;86(1):28-31. doi: 10.1038/clpt.2009.30.
Pharmacogenomics aims to use molecular genetic markers to predict treatment outcome. Indeed, within the past decade there has been a rapid emergence of pharmacogenetic tests to aid clinicians in predicting efficacy or toxicity for some drugs. Despite this major advance in therapeutic drug management, there remain challenges to the appropriate use of pharmacogenetic tests. We discuss UGT1A1 pharmacogenetic testing to illustrate the knowledge gaps impeding widespread use of pharmacogenetic tests in the clinical setting.
药物基因组学旨在利用分子遗传标记来预测治疗效果。事实上,在过去十年中,药物遗传学检测迅速涌现,以帮助临床医生预测某些药物的疗效或毒性。尽管在治疗药物管理方面取得了这一重大进展,但在合理使用药物遗传学检测方面仍存在挑战。我们讨论尿苷二磷酸葡萄糖醛酸基转移酶1A1(UGT1A1)药物遗传学检测,以说明阻碍药物遗传学检测在临床环境中广泛应用的知识空白。