Winkelman John W, Redline Susan, Baldwin Carol M, Resnick Helaine E, Newman Anne B, Gottlieb Daniel J
Harvard Medical School, Boston, MA, USA.
Sleep. 2009 Jun;32(6):772-8. doi: 10.1093/sleep/32.6.772.
Sleep disturbance is the primary clinical morbidity of restless legs syndrome (RLS). To date, sleep disturbance in RLS has been measured in (1) clinical samples with polysomnography (PSG) or (2) population-based samples by self-report. The objective of this study was to analyze sleep by PSG in a population-based sample with symptoms of RLS.
Cross-sectional observational study.
Community-based.
3433 older men and women.
None.
RLS was evaluated using an 8-item self-administered questionnaire based on NIH diagnostic criteria and required symptoms occurring > or = five times per month and associated with at least moderate distress. Health-related quality of life (HRQOL) was determined using the SF-36. Unattended, in-home PSG was performed. Data were assessed using general linear models with adjustment for demographic, health-related variables, and apnea-hypopnea index (AHI). Subjects with RLS had longer adjusted mean sleep latency (39.8 vs 26.4 min, P < 0.0001) and higher arousal index (20.1 vs 18.0, P = 0.0145) than those without RLS. Sleep latency increased progressively as the frequency of RLS symptoms increased from 5-15 days per month to 6-7 days per week. No differences in sleep stage percentages were observed between participants with and without RLS. Subjects with RLS also reported poorer HRQOL in all physical domains as well as in the Mental Health and Vitality domains.
These novel PSG data from a nonclinical, community-based sample of individuals with RLS document sleep disturbance in the home even in individuals with intermittent symptoms.
睡眠障碍是不宁腿综合征（RLS）的主要临床发病表现。迄今为止，RLS患者的睡眠障碍评估方式有两种：（1）通过多导睡眠图（PSG）对临床样本进行评估；（2）通过自我报告对基于人群的样本进行评估。本研究的目的是通过PSG对有RLS症状的基于人群的样本进行睡眠分析。
横断面观察性研究。
社区。
3433名老年男性和女性。
无。
基于美国国立卫生研究院（NIH）诊断标准，采用一份8项自评问卷对RLS进行评估，要求症状每月出现≥5次且至少伴有中度痛苦。使用SF-36量表确定健康相关生活质量（HRQOL）。进行无人值守的家庭PSG监测。数据采用一般线性模型进行评估，并对人口统计学、健康相关变量和呼吸暂停低通气指数（AHI）进行校正。与无RLS的受试者相比，RLS患者的校正后平均睡眠潜伏期更长（39.8分钟对26.4分钟，P<0.0001），觉醒指数更高（20.1对18.0，P = 0.0145）。随着RLS症状出现频率从每月5 - 15天增加到每周6 - 7天，睡眠潜伏期逐渐延长。有RLS和无RLS的参与者之间在睡眠阶段百分比方面未观察到差异。RLS患者在所有身体领域以及心理健康和活力领域也报告了较差的HRQOL。
这些来自非临床、基于社区的RLS个体样本的全新PSG数据表明，即使是有间歇性症状的个体在家中也存在睡眠障碍。
