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一种用于千伏光子、兆伏光子以及电子、质子和碳离子束的商用光激励发光探测器的能量依赖性和剂量响应。

The energy dependence and dose response of a commercial optically stimulated luminescent detector for kilovoltage photon, megavoltage photon, and electron, proton, and carbon beams.

作者信息

Reft Chester S

机构信息

Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois 60637, USA.

出版信息

Med Phys. 2009 May;36(5):1690-9. doi: 10.1118/1.3097283.

DOI:10.1118/1.3097283
PMID:19544786
Abstract

Optically stimulated luminescent detectors, which are widely used in radiation protection, offer a number of potential advantages for application in radiation therapy dosimetry. Their introduction into this field has been somewhat hampered by the lack of information on their radiation response in megavoltage beams. Here the response of a commercially available optically stimulated luminescent detector (OSLD) is determined as a function of energy, absorbed dose to water, and linear energy transfer (LET). The detector response was measured as a function of energy for absorbed doses from 0.5 to 4.0 Gy over the following ranges: 125 kVp to 18 MV for photons, 6-20 MeV for electrons, 50-250 MeV for protons, and 290 MeV/u for the carbon ions. For the low LET beams, the response of the detector was linear up to 2 Gy with supralinearity occurring at higher absorbed doses. For the kilovoltage photons, the detector response relative to 6 MV increased with decreasing energy due to the higher atomic number of aluminum oxide (11.2) relative to water (7.4). For the megavoltage photons and electrons, the response was independent of energy. The response for protons was also independent of energy, but it was about 6% higher than its response to 6 MV photons. For the carbon ions, the dose response was linear for a given LET from 0.5 to 4.0 Gy, and no supralinearity was observed. However, it did exhibit LET dependence on the response relative to 6 MV photons decreasing from 1.02 at 1.3 keV/microm to 0.41 at 78 keV/microm. These results provide additional information on the dosimetric properties for this particular OSL detector and also demonstrate the potential for their use in photon, electron, and proton radiotherapy dosimetry with a more limited use in high LET radiotherapy dosimetry.

摘要

光激励发光探测器在辐射防护中被广泛应用,在放射治疗剂量测定中具有许多潜在优势。然而,由于缺乏关于其在兆伏级射束中辐射响应的信息,它们在该领域的应用受到了一定阻碍。本文确定了一种市售光激励发光探测器(OSLD)的响应与能量、水吸收剂量以及线能量转移(LET)的函数关系。在以下能量范围内,测量了探测器响应随能量的变化,吸收剂量范围为0.5至4.0 Gy:光子能量从125 kVp至18 MV,电子能量为6 - 20 MeV,质子能量为50 - 250 MeV,碳离子能量为290 MeV/u。对于低LET射束,探测器响应在2 Gy以下呈线性,在更高吸收剂量时出现超线性。对于千伏级光子,由于相对于水(7.4),氧化铝(11.2)的原子序数更高,探测器相对于6 MV的响应随能量降低而增加。对于兆伏级光子和电子,响应与能量无关。质子的响应也与能量无关,但比其对6 MV光子的响应高约6%。对于碳离子,在给定LET下,剂量响应在0.5至4.0 Gy范围内呈线性,未观察到超线性。然而,相对于6 MV光子,其响应确实表现出LET依赖性,从1.3 keV/μm时的1.02降至78 keV/μm时的0.41。这些结果提供了关于这种特定OSL探测器剂量学特性的更多信息,也证明了它们在光子、电子和质子放射治疗剂量测定中的应用潜力,而在高LET放射治疗剂量测定中的应用较为有限。

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