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解决诊断 X 射线剂量学中的挑战:基于 AlO:C 的光激励发光剂量计的不确定度和修正。

Addressing challenges in diagnostic X-ray dosimetry: uncertainties and corrections for AlO:C-based optically stimulated luminescent dosimeters.

机构信息

Department of Biomedical Imaging, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.

Medical Physics Laboratory, Radiation Safety and Health Division, Malaysian Nuclear Agency, 43000, Bangi, Kajang, Selangor, Malaysia.

出版信息

Phys Eng Sci Med. 2024 Sep;47(3):821-832. doi: 10.1007/s13246-024-01407-y. Epub 2024 Mar 25.

DOI:10.1007/s13246-024-01407-y
PMID:38526646
Abstract

The use of AlO:C-based optically stimulated luminescent dosimeters (OSLDs) in diagnostic X-ray is a challenge because of their energy dependence (ED) and variability of element sensitivity factors (ESFs). This study aims to develop a method to determine ED and ESFs of Landauer nanoDot™ OSLDs for clinical X-ray and investigate the uncertainties associated with ESF and ED correction factors. An area of 2 × 2 cm at the central axis of the X-ray field was used to establish the ESFs. A total of 80 OSLDs were categorized into "controlled" (n = 40) and "less-controlled" groups (n = 40). The ESFs of the OSLDs were determined using an 80 kVp X-ray beam quality in free-air geometry. The OSLDs were cross-calibrated with an ion chamber to establish the average calibration coefficient and ESFs. The OSLDs were then irradiated at tube potentials ranging from 50 to 150 kVp to determine their ED. The uniformity of the X-ray field was ± 1.5% at 100 cm source-to-surface distance. The batch homogeneities of user-defined ESFs were 2.4% and 8.7% for controlled and less-controlled OSLDs, respectively. The ED of OSLDs ranged from 1.125 to 0.812 as tube potential increased from 50 kVp to 150 kVp. The total uncertainty of OSLDs, without ED correction, could be as high as 16%. After applying ESF and ED correction, the total uncertainties were reduced to 6.3% in controlled OLSDs and 11.6% in less-controlled ones. OSLDs corrected with user-defined ESF and ED can reduce the uncertainty of dose measurements in diagnostic X-rays, particularly in managing less-controlled OSLDs.

摘要

基于 AlO:C 的光激励发光剂量计(OSLD)在诊断 X 射线中的应用具有挑战性,因为它们存在能量依赖性(ED)和元素灵敏度因子(ESF)的可变性。本研究旨在开发一种用于临床 X 射线的 Landauer nanoDot™ OSLD 的 ED 和 ESF 确定方法,并研究与 ESF 和 ED 校正因子相关的不确定度。使用 X 射线射野的中心轴上的 2×2 cm 区域来建立 ESF。将总共 80 个 OSLD 分为“受控”(n=40)和“较少受控”组(n=40)。在自由空气几何形状下使用 80 kVp X 射线束质量确定 OSLD 的 ESF。通过与电离室交叉校准来建立平均校准系数和 ESF。然后,将 OSLD 在管电压范围从 50 至 150 kVp 下进行照射,以确定其 ED。在 100 cm 源-皮肤距离处,X 射线场的均匀性为±1.5%。对于受控和较少受控的 OSLD,用户定义的 ESF 的批次均匀性分别为 2.4%和 8.7%。随着管电压从 50 kVp 增加到 150 kVp,OSLD 的 ED 从 1.125 变化到 0.812。未进行 ED 校正时,OSLD 的总不确定度可能高达 16%。应用 ESF 和 ED 校正后,在受控 OSLD 中总不确定度降低至 6.3%,在较少受控的 OSLD 中降低至 11.6%。使用用户定义的 ESF 和 ED 校正的 OSLD 可以降低诊断 X 射线中剂量测量的不确定性,特别是在管理较少受控的 OSLD 时。

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本文引用的文献

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Phys Imaging Radiat Oncol. 2019 Sep 12;11:63-68. doi: 10.1016/j.phro.2019.08.004. eCollection 2019 Jul.
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一种实用的纳米点 OSLD 再利用方法,并可预测至少 7000cGy 的灵敏度。
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CHARACTERISATION AND EVALUATION OF AL2O3:C-BASED OPTICALLY STIMULATED LUMINESCENT DOSEMETER SYSTEM FOR DIAGNOSTIC X-RAYS: PERSONAL AND IN VIVO DOSIMETRY.用于诊断X射线的基于Al2O3:C的光激励发光剂量计系统的表征与评估:个人及体内剂量测定
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On the Use of Optically Stimulated Luminescent Dosimeter for Surface Dose Measurement during Radiotherapy.关于光学激发发光剂量计在放射治疗期间表面剂量测量中的应用。
PLoS One. 2015 Jun 8;10(6):e0128544. doi: 10.1371/journal.pone.0128544. eCollection 2015.
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