Ferguson K P, Lambe D W, Keplinger J L, Kalbfleisch J H
Department of Microbiology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City 37614.
Can J Microbiol. 1991 Sep;37(9):722-4. doi: 10.1139/m91-124.
Staphylococcus schleiferi, Staphylococcus lugdunensis, and Staphylococcus epidermidis produce a high incidence of abscesses in a mouse model with an implanted foreign body. We investigated the significance of the foreign body in this process. Fourteen strains of S. schleiferi, S. epidermidis, and S. lugdunensis were tested in our model. A preadhered foreign body was implanted into one mouse group, followed by injection of a test strain. Another group received injection without implant. Abscesses were assessed at 7 days; foreign bodies and infected tissues were cultured. The percent of samples that developed abscesses or were culture positive was compared for each strain. Nearly all mice infected with S. schleiferi developed abscesses and were culture positive. The foreign body made no difference in abscess formation for three of four S. schleiferi but increased the incidence of both organism recovery and abscess for three of five S. epidermidis. The foreign body enhanced abscess formation for four of five S. lugdunensis, with all five strains yielding significantly more culture recovery. Although the pathogenicity of nine strains was increased by the foreign body, five strains yielded high abscess and culture recovery rates that were not enhanced by its presence.
施氏葡萄球菌、路邓葡萄球菌和表皮葡萄球菌在植入异物的小鼠模型中引发脓肿的发生率很高。我们研究了异物在此过程中的意义。在我们的模型中测试了14株施氏葡萄球菌、表皮葡萄球菌和路邓葡萄球菌。将预先附着有异物的物体植入一组小鼠体内，随后注射测试菌株。另一组只接受注射而不植入异物。在7天时评估脓肿情况；对异物和感染组织进行培养。比较每种菌株形成脓肿或培养呈阳性的样本百分比。几乎所有感染施氏葡萄球菌的小鼠都形成了脓肿且培养呈阳性。对于4株施氏葡萄球菌中的3株，异物对脓肿形成没有影响，但对于5株表皮葡萄球菌中的3株，异物增加了细菌检出率和脓肿发生率。对于5株路邓葡萄球菌中的4株，异物增强了脓肿形成，所有5株菌株的培养物回收率都显著更高。虽然异物增加了9株菌株的致病性，但有5株菌株产生了高脓肿率和培养物回收率，异物的存在并未增强这些比率。
