表观遗传对大脑发育和可塑性的影响。
Epigenetic influences on brain development and plasticity.
作者信息
Fagiolini Michela, Jensen Catherine L, Champagne Frances A
机构信息
F.M. Kirby Neurobiology Center, Children's Hospital, Harvard Medical School, 300 Longwood Avenue, CLS 13034, Boston, MA 02115, United States.
出版信息
Curr Opin Neurobiol. 2009 Apr;19(2):207-12. doi: 10.1016/j.conb.2009.05.009. Epub 2009 Jun 21.
Abstract
A fine interplay exists between sensory experience and innate genetic programs leading to the sculpting of neuronal circuits during early brain development. Recent evidence suggests that the dynamic regulation of gene expression through epigenetic mechanisms is at the interface between environmental stimuli and long lasting molecular, cellular and complex behavioral phenotypes acquired during periods of developmental plasticity. Understanding these mechanisms may give insight into the formation of critical periods and provide new strategies for increasing plasticity and adaptive change in adulthood.
摘要
在早期大脑发育过程中，感觉经验与先天遗传程序之间存在着精细的相互作用，从而导致神经回路的塑造。最近的证据表明，通过表观遗传机制对基因表达的动态调控处于环境刺激与在发育可塑性时期获得的持久分子、细胞及复杂行为表型之间的界面。了解这些机制可能有助于深入了解关键期的形成，并为增加成年期的可塑性和适应性变化提供新策略。
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