Harris David G, Coetzee Andre R, Augustyn Johan T, Saaiman Andre
Department of Cardiac Surgery and Cardiology, Kuils River Private Hospital, Cape Town, South Africa.
Heart Surg Forum. 2009 Jun;12(3):E163-7. doi: 10.1532/HSF98.20091046.
Repeat coronary artery bypass surgery has increased risks compared with the first operation, including low cardiac output and injury to patent grafts. The left thoracotomy approach has been advocated specifically in patients with intact grafts of the left internal mammary artery (LIMA) to the left anterior descending coronary artery (LAD) needing lateral wall grafting. We have evaluated this technique in conjunction with an off-pump procedure in all patients.
There were 55 patients over an 8-year period, and 6 (10.9%) were female. The mean age was 63.2 years (range, 41-82 years), and the age at the time of the previous operation was 51.7 years (range, 31-69 years). Four patients (7.2%) underwent a third operation. Comorbidities were diabetes mellitus (25 patients, 45.5%), renal impairment (8 patients, 14.5%), calcified ascending aorta (9 patients, 16.4%), carotid disease (4 patients, 7.2%), and peripheral vascular disease (11 patients, 20.0%). Fifteen patients (27.2%) had previous coronary stents. Nine patients (16.4%) had a preoperative intra-aortic balloon pump. Predicted mortality (logistic EuroSCORE) was 14.2%.
Forty-three patients (78.1%) had intact LIMA-to-LAD grafts. Twenty-two patients (40.0%) required a major posterolateral thoracotomy, and 33 patients (60.0%) had a minor thoracotomy. Thirteen patients (23.6%) had stents placed as a hybrid procedure during the same admission. Thirteen patients (23.6%) additionally underwent anterior wall grafting (LAD to the first marginal area). The LIMA was used in 7 patients where it had not been used before. There were 91 distal grafts (including 4 sequentials). We performed 54 venous grafts and 26 radial artery grafts. Twenty-one patients (38.1%) had 1 distal graft, 32 patients (58.1%) had 2 grafts, and 2 patients (3.6%) had 3 distal grafts performed (mean, 1.6 grafts/patient). The proximal graft site was the proximal descending aorta in 20.0% of the patients, the distal aorta in 67.5%, and the subclavian artery in 12.5%. In 10 patients (18.2%), the distal branches of the right coronary (posterior descendens or right posterolateral) were grafted. No patient required conversion to cardiopulmonary bypass or sternotomy. No patient needed an intra-aortic balloon pump postoperatively. The mean blood loss (24 hours) was 380 mL (range, 125-1100 mL), the mean ventilation time was 4.8 hours (range, 0-12 hours), the mean intensive care unit stay was 2.7 days (range, 2-8 days), and the mean hospital stay was 6.3 days (range, 5-20 days). There was 1 postoperative death (1.8% mortality). One late death occurred on follow-up. Four patients underwent cardiac catheterization for chest pain, and the grafts were shown to be open.
The procedure is safe, especially in patients with intact LIMA-to-LAD grafts needing lateral and inferior wall revascularization. Multislice computed tomography scanning allows better preoperative planning, especially regarding the site of implantation of the proximal graft, allowing a less invasive incision. The off-pump technique preserves cardiac and pulmonary function. The in-hospital death rate (1.8%) compares very well with the EuroSCORE-predicted mortality (14.2%).
与首次手术相比,再次冠状动脉搭桥手术风险增加,包括低心排血量和对通畅移植血管的损伤。对于左乳内动脉(LIMA)至左前降支冠状动脉(LAD)移植血管完好且需要侧壁移植的患者,特别提倡采用左胸廓切开入路。我们在所有患者中结合非体外循环手术对该技术进行了评估。
8年间共55例患者,其中6例(10.9%)为女性。平均年龄63.2岁(范围41 - 82岁),上次手术时年龄为51.7岁(范围31 - 69岁)。4例患者(7.2%)接受了第三次手术。合并症包括糖尿病(25例,45.5%)、肾功能损害(8例,14.5%)、升主动脉钙化(9例,16.4%)、颈动脉疾病(4例,7.2%)和外周血管疾病(11例,20.0%)。15例患者(27.2%)曾有冠状动脉支架置入史。9例患者(16.4%)术前使用过主动脉内球囊泵。预测死亡率(逻辑欧洲心脏手术风险评估系统)为14.2%。
43例患者(78.1%)LIMA至LAD移植血管完好。22例患者(40.0%)需要进行大的后外侧胸廓切开术,33例患者(60.0%)进行了小的胸廓切开术。13例患者(23.6%)在同一住院期间作为杂交手术置入了支架。13例患者(23.6%)另外进行了前壁移植(LAD至第一边缘区域)。7例患者使用了之前未用过的LIMA。共进行了91次远端移植(包括4次序贯移植)。我们进行了54次静脉移植和26次桡动脉移植。21例患者(38.1%)有1次远端移植,32例患者(58.1%)有2次移植,2例患者(3.6%)进行了3次远端移植(平均每位患者1.6次移植)。近端移植部位在20.0%的患者中为降主动脉近端,67.5%为主动脉远端,12.5%为锁骨下动脉。10例患者(18.2%)对右冠状动脉的远端分支(后降支或右后外侧支)进行了移植。没有患者需要转为体外循环或开胸手术。没有患者术后需要主动脉内球囊泵。平均失血量(24小时)为380 mL(范围125 - 1100 mL),平均通气时间为4.8小时(范围0 - 12小时),平均重症监护病房停留时间为2.7天(范围2 - 8天),平均住院时间为6.3天(范围5 - 20天)。术后有1例死亡(死亡率1.8%)。随访中有1例晚期死亡。4例患者因胸痛接受了心脏导管检查,显示移植血管通畅。
该手术是安全的,尤其对于LIMA至LAD移植血管完好且需要侧壁和下壁血运重建的患者。多层螺旋CT扫描有助于更好地进行术前规划,特别是关于近端移植血管的植入部位,从而允许采用侵入性较小的切口。非体外循环技术可保留心脏和肺功能。住院死亡率(1.8%)与欧洲心脏手术风险评估系统预测的死亡率(14.2%)相比非常低。