Chen Xin, Xu Ming, Wang Li-ming, Shi Kai-hu, Jiang Ying-shuo, Liu Pei-sheng
Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing 210006, China.
Zhonghua Wai Ke Za Zhi. 2006 Jul 15;44(14):940-2.
To review and summarize the early outcomes and clinical experience of coronary endarterectomy (CE) and bypass grafting without cardiopulmonary bypass for patients with diffused coronary artery disease.
From May 2003 to May 2005, 53 patients with diffused coronary artery disease underwent CE and bypass grafting without cardiopulmonary bypass. There were 41 males and 12 females aged from 55 to 79 (mean 64 +/- 7) years old. 72% patients (38/53) were in Canadian Cardiac Society (CCS) angina class III and IV. 49% (26/53) had history of myocardial infarction. Coronary angiogram revealed that 3 cases had double vessels disease and, other 50 cases had triple vessels disease with 9 left main stem disease. The left ventricular ejection fraction (LVEF) ranged from 0.26 to 0.65 (0.52 +/- 0.17). Seventy endarterectomies were performed in 53 patients totally which included 38 in left anterior descending artery (LAD), 8 in circumflex artery and 24 in right coronary artery. Five cases received on-lay venous patch after CE in LAD and then grafted by internal mammary artery (IMA) on the patch. There were 53 left IMAs, 2 radial arteries, others were great saphenous veins, the mean number of grafts was 3.8 +/- 1.1 with index of completeness of revascularization (ICR) 1.03 +/- 0.07.
Intra-operative graft flow-meter was used to check the flow in the grafts before chest closure. There is no death in the group. Sixty-three (90%) out of 70 grafts after CE showed a satisfactory grafts flow intra-operatively. Two patients had peri-operative myocardial infarctions but neither had hemodynamic changes. All patients discharged uneventfully with mean hospital stay 9 days postoperatively. Forty-four patients had 6 to 29 months follow-up with no angina re-occurrence. Six patients had coronary angiogram 3 to 27 months postoperatively with all patent grafts to the CE coronaries.
CE and bypass grafting without cardiopulmonary bypass is technically feasible and can be performed safely in patients with diffused coronary artery disease with increased completeness of myocardial revascularization.
回顾并总结冠状动脉内膜切除术(CE)及非体外循环下冠状动脉旁路移植术治疗弥漫性冠状动脉疾病患者的早期疗效及临床经验。
2003年5月至2005年5月,53例弥漫性冠状动脉疾病患者接受了CE及非体外循环下冠状动脉旁路移植术。其中男性41例,女性12例,年龄55至79岁(平均64±7岁)。72%的患者(38/53)为加拿大心血管学会(CCS)心绞痛Ⅲ级和Ⅳ级。49%(26/53)有心肌梗死病史。冠状动脉造影显示,3例为双支血管病变,其余50例为三支血管病变,其中9例有左主干病变。左心室射血分数(LVEF)为0.26至0.65(0.52±0.17)。53例患者共行70次内膜切除术,其中左前降支(LAD)38次,回旋支8次,右冠状动脉24次。5例患者在LAD行CE后接受了静脉补片,然后在补片上用乳内动脉(IMA)进行移植。共使用53支左IMA、2支桡动脉,其余为大隐静脉,平均移植血管数为3.8±1.1,血管重建完全指数(ICR)为1.03±0.07。
术中使用移植血管流量计在关胸前行移植血管流量检查。该组无死亡病例。CE术后70支移植血管中有63支(90%)术中显示移植血管流量满意。2例患者发生围手术期心肌梗死,但均未出现血流动力学改变。所有患者术后均顺利出院,平均住院时间为9天。44例患者接受了6至29个月的随访,无心绞痛复发。6例患者在术后3至27个月进行了冠状动脉造影,所有移植至CE冠状动脉的血管均通畅。
CE及非体外循环下冠状动脉旁路移植术在技术上是可行的,对于弥漫性冠状动脉疾病患者可安全实施,且心肌血运重建的完整性增加。