Peng Wen Hui, Lu Lin, Zhang Qi, Zhang Rui Yan, Wang Ling Jie, Yan Xiao Xiang, Chen Qiu Jing, Shen Wei Feng
Department of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
Clin Chem Lab Med. 2009;47(8):917-22. doi: 10.1515/CCLM.2009.215.
rs1333049 polymorphism on chromosome 9p21 has been shown to affect susceptibility to coronary artery disease (CAD) in Caucasians. This study examined the association of rs1333049 with myocardial infarction (MI), angiographic severity of CAD and clinical outcome after a first acute MI in Han Chinese.
rs1333049 polymorphism was genotyped in 520 patients with a first acute MI and in 560 controls. The number of angiographically documented diseased coronary arteries (luminal diameter stenosis > or = 50%), echocardiographic left ventricular ejection fraction (LVEF), and major adverse cardiac events (MACE) during follow-up (mean, 29+/-15 months) were recorded.
Patients with MI had higher frequencies of the CC genotype (30.0% vs. 20.7%) or C allele (55.5% vs. 46.2%) compared with controls (all p<0.01). rs1333049 polymorphism was strongly associated with MI [odds ratio (OR) 1.48, 95% confidence interval (CI) 1.22-1.79] after adjusting for traditional risk factors. Although longer hospitalization stay was observed in patients with the rs1333049-C allele, this polymorphism was not related to angiographic severity of CAD, LVEF, and occurrence of MACE after MI.
This study demonstrates an association of rs1333049 polymorphism locus on chromosome 9p21 with risk for MI, but not with post-MI prognosis in Han Chinese.
9号染色体p21区域的rs1333049多态性已被证明会影响白种人患冠状动脉疾病（CAD）的易感性。本研究调查了rs1333049与汉族人群首次急性心肌梗死（MI）、CAD血管造影严重程度及首次急性心肌梗死后临床结局之间的关联。
对520例首次急性心肌梗死患者和560例对照者进行rs1333049多态性基因分型。记录血管造影显示的病变冠状动脉数量（管腔直径狭窄≥50%）、超声心动图测定的左心室射血分数（LVEF）以及随访期间（平均29±15个月）的主要不良心脏事件（MACE）。
与对照组相比，心肌梗死患者CC基因型（30.0%对20.7%）或C等位基因（55.5%对46.2%）的频率更高（均p<0.01）。在校正传统危险因素后，rs1333049多态性与心肌梗死显著相关[比值比（OR）1.48，95%置信区间（CI）1.22 - 1.79]。虽然携带rs1333049 - C等位基因的患者住院时间更长，但该多态性与CAD血管造影严重程度、LVEF以及心肌梗死后MACE的发生无关。
本研究表明9号染色体p21区域的rs1333049多态性位点与汉族人群心肌梗死风险相关，但与心肌梗死后预后无关。
