Oncological Surgical Department, University of Turin, 10126 Turin, Italy.
Colorectal Dis. 2010 Aug;12(8):799-803. doi: 10.1111/j.1463-1318.2009.01960.x. Epub 2009 Jun 22.
Human papillomavirus is the most common cause of sexually transmitted disease. It is associated with immunosuppression and shows a marked tendency to recur. We investigated a natural immunostimulant aimed to reduce recurrence.
A randomized controlled study was carried out including 261 patients allocated to surgical excision alone (control group; n = 122) and surgical excision plus postoperative immunostimulation for 30 days with a natural product (STET; study group; n = 139). Patients with HIV positivity were excluded. All patients gave fully informed consent.
The patients were followed for 6 months after surgery. Recurrence occurred in 7.2% (10/139) in the study group and in 27.1% (33/122) in the control group (P < 0.0001). There were no significant differences in the sex, sexual orientation, number of lesions, time to diagnosis and treatment or localization of lesions in the two groups.
Immunostimulation using a natural product significantly reduced the incidence of recurrence of anal condylomata in patients undergoing surgical excision.
人乳头瘤病毒是最常见的性传播疾病病原体。它与免疫抑制有关，且具有明显的复发倾向。我们研究了一种天然免疫刺激剂，旨在减少复发。
进行了一项随机对照研究，共纳入 261 例患者，分为单纯手术切除组（对照组；n=122）和手术切除后加用天然产品进行 30 天免疫刺激组（研究组；n=139）。排除 HIV 阳性患者。所有患者均完全知情同意。
术后 6 个月对患者进行随访。研究组复发率为 7.2%（10/139），对照组为 27.1%（33/122）（P<0.0001）。两组患者的性别、性取向、病变数量、诊断和治疗时间或病变部位无显著差异。
在接受手术切除的患者中使用天然产品进行免疫刺激可显著降低肛门尖锐湿疣的复发率。
