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免疫状态与人类免疫缺陷病毒阳性患者复发性肛门尖锐湿疣的关联。

Association of immune status with recurrent anal condylomata in human immunodeficiency virus-positive patients.

作者信息

Sung Ji Hyun, Ahn Eun Jung, Oh Heung-Kwon, Park Sei Hyeog

机构信息

Department of Surgery, National Medical Center, Seoul, Korea.

出版信息

J Korean Soc Coloproctol. 2012 Dec;28(6):294-8. doi: 10.3393/jksc.2012.28.6.294. Epub 2012 Dec 31.

DOI:10.3393/jksc.2012.28.6.294
PMID:23346507
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3548143/
Abstract

PURPOSE

An anal condyloma is a proliferative disease of the genital epithelium caused by the human papillomavirus. This condition is most commonly seen in male homosexuals and is frequently recurrent. Some reports have suggested that immunosuppression is a risk factor for recurrence of a condyloma. Thus, we investigated the risk factors for a recurrent anal condyloma in human immunodeficiency virus (HIV)-positive patients.

METHODS

We retrospectively analyzed 85 consecutive patients who were diagnosed with and underwent surgery for an anal condyloma from January 2007 to December 2011. Outcomes were analyzed based clinical and immunologic data.

RESULTS

Recurrent anal condylomata were found in 25 patients (29.4%). Ten cases (40.0%) were within postoperative 3 months. At postoperative 6 months, the CD4 lymphocyte count in the recurrent group was lower than it was in the nonrecurrent group (P = 0.023).

CONCLUSION

CD4-mediated immunosuppression is a risk factor for recurrent anal condylomata in HIV-positive patients.

摘要

目的

肛门尖锐湿疣是由人乳头瘤病毒引起的生殖器上皮增生性疾病。这种情况最常见于男性同性恋者，且常复发。一些报告表明免疫抑制是尖锐湿疣复发的一个危险因素。因此，我们调查了人类免疫缺陷病毒（HIV）阳性患者复发性肛门尖锐湿疣的危险因素。

方法

我们回顾性分析了2007年1月至2011年12月期间连续85例被诊断为肛门尖锐湿疣并接受手术治疗的患者。根据临床和免疫学数据对结果进行分析。

结果

25例患者（29.4%）出现复发性肛门尖锐湿疣。10例（40.0%）在术后3个月内复发。术后6个月时，复发组的CD4淋巴细胞计数低于未复发组（P = 0.023）。

结论

CD4介导的免疫抑制是HIV阳性患者复发性肛门尖锐湿疣的一个危险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1051/3548143/db469f355848/jksc-28-294-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1051/3548143/db469f355848/jksc-28-294-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1051/3548143/db469f355848/jksc-28-294-g001.jpg

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