携带R质粒的大肠杆菌中氯霉素乙酰转移酶的环腺苷酸依赖性和非依赖性产生
Cyclic adenylic acid-dependent and -independent production of chloramphenicol acetyltransferase in Escherichia coli carrying R plasmids.
作者信息
Yokota T, Kuwahara R, Hagiwara S, Kuwahara S
出版信息
Antimicrob Agents Chemother. 1977 Jun;11(6):952-5. doi: 10.1128/AAC.11.6.952.
Abstract
A plasmid-specified, inducible, but cyclic adenylic acid (cAMP)-independent resistance to chloramphenicol (CM) is reported. The resistance level to CM was increased two- to fourfold by treatment with a small amount of CM for a short period in Escherichia coli strains carrying the R plasmid pJY1, which was obtained from a clinical isolate of Vibrio cholerae. Though cAMP was required for production of CM acetyltransferase (CATase) in cAMP-deficient mutants of E. coli carrying the R100 plasmid, the same species harboring pJY1 did not require cAMP for production of the enzyme. The possibility of a mechanism other than CATase activity for the CM resistance conferred by R plasmids is discussed.
摘要
据报道，存在一种由质粒指定的、可诱导的、但不依赖环腺苷酸（cAMP）的氯霉素（CM）抗性。在携带从霍乱弧菌临床分离株获得的R质粒pJY1的大肠杆菌菌株中，通过用少量CM短期处理，对CM的抗性水平提高了两到四倍。虽然在携带R100质粒的大肠杆菌cAMP缺陷型突变体中，产生CM乙酰转移酶（CATase）需要cAMP，但携带pJY1的同一菌株产生该酶不需要cAMP。讨论了R质粒赋予CM抗性的机制除CATase活性之外的其他可能性。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Conjugal fertility associated with resistance factor R in Escherichia coli.大肠杆菌中与抗性因子R相关的接合生殖力
J Bacteriol. 1962 Nov;84(5):902-10. doi: 10.1128/jb.84.5.902-910.1962.
3
Transduction of linked genetic characters of the host by bacteriophage P1.噬菌体P1对宿主连锁遗传性状的转导
Virology. 1955 Jul;1(2):190-206. doi: 10.1016/0042-6822(55)90016-7.
4
Characterization of chloramphenicol acetyltransferase from chloramphenicol-resistant Staphylococcus aureus.耐氯霉素金黄色葡萄球菌中氯霉素乙酰转移酶的特性分析
J Bacteriol. 1968 Jan;95(1):28-36. doi: 10.1128/jb.95.1.28-36.1968.
5
Characterization of Escherichia coli flagellar mutants that are insensitive to catabolite repression.对分解代谢物阻遏不敏感的大肠杆菌鞭毛突变体的表征
J Bacteriol. 1974 Dec;120(3):1196-203. doi: 10.1128/jb.120.3.1196-1203.1974.
6
Adenosine 3',5'-cyclic monophosphate-deficient mutants of Vibrio cholerae.霍乱弧菌3',5'-环磷酸腺苷缺陷型突变体
J Bacteriol. 1974 Oct;120(1):106-13. doi: 10.1128/jb.120.1.106-113.1974.
7
Stimulation by cyclic AMP and ppGpp of chloramphenicol acetyl transferase synthesis.环磷酸腺苷（cAMP）和鸟苷四磷酸（ppGpp）对氯霉素乙酰转移酶合成的刺激作用。
Nat New Biol. 1973 Feb 21;241(112):237-9. doi: 10.1038/newbio241237a0.
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Adenosine 3',5'-cyclic monophosphate regulation of chloramphenicol acetyltransferase synthesis in vitro from P1CM DNA.3',5'-环磷酸腺苷对来自P1CM DNA的氯霉素乙酰转移酶体外合成的调节
Virology. 1973 Feb;51(2):509-11. doi: 10.1016/0042-6822(73)90453-4.
9
Requirement of adenosine-3',5'-cyclic monophosphate for L-arabinose isomerase synthesis in Escherichia coli.大肠杆菌中L-阿拉伯糖异构酶合成对3',5'-环磷酸腺苷的需求
J Bacteriol. 1973 Mar;113(3):1412-8. doi: 10.1128/jb.113.3.1412-1418.1973.
10
Lac DNA, RNA polymerase and cyclic AMP receptor protein, cyclic AMP, lac repressor and inducer are the essential elements for controlled lac transcription.乳糖操纵子DNA、RNA聚合酶、环腺苷酸受体蛋白、环腺苷酸、乳糖阻遏物和诱导物是乳糖转录调控的基本要素。
Nat New Biol. 1971 Jun 2;231(22):139-42. doi: 10.1038/newbio231139a0.
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