大肠杆菌K-12中由质粒R26和R55-1所指定的非酶促氯霉素抗性决定簇不会赋予对氟化类似物的高水平抗性。
Nonenzymatic chloramphenicol resistance determinants specified by plasmids R26 and R55-1 in Escherichia coli K-12 do not confer high-level resistance to fluorinated analogs.
作者信息
Dorman C J, Foster T J
出版信息
Antimicrob Agents Chemother. 1982 Nov;22(5):912-4. doi: 10.1128/AAC.22.5.912.
Abstract
Plasmids R26 (Inc P) and R55-1 (Inc C) specify inducible nonenzymatic resistance to chloramphenicol. Escherichia coli K-12 strains harboring these plasmids encoded low-level resistance to thiamphenicol analogs Sch 25298 and Sch 25393 but failed to specify resistance to the fluorinated chloramphenicol analog Sch 24893. The analogs were efficient inducers of high-level chloramphenicol resistance.
摘要
质粒R26（Inc P）和R55 - 1（Inc C）可产生对氯霉素的诱导型非酶抗性。携带这些质粒的大肠杆菌K - 12菌株对甲砜霉素类似物Sch 25298和Sch 25393编码低水平抗性，但对氟化氯霉素类似物Sch 24893不产生抗性。这些类似物是高水平氯霉素抗性的有效诱导剂。
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