Leon A S, Connett J
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55455.
Int J Epidemiol. 1991 Sep;20(3):690-7. doi: 10.1093/ije/20.3.690.
The effect of habitual leisure time physical activity (LTPA) on the 10.5-year total and cause-specific mortality rates was studied in 12,138 middle-aged men at high risk for coronary heart disease (CHD) who participated in the MRFIT. The level of LTPA as determined by the Minnesota questionnaire was inversely related to rate of death from cardiovascular (CVD), coronary heart disease (CHD), and all-causes, but was unrelated to the cancer death rate. The least active men (LTPA tertile 1) had excess mortality rates of 22%, 27%, and 15% for CVD, CHD, all-causes, respectively, as compared to more active men in the middle third (tertile 2). Additional LTPA (tertile 3) was not associated with further attenuation of mortality rates. Proportional hazards regression analysis only slightly weakened risk differentials. This study supports previous observations that regular LTPA is associated with a reduced rate of CVD mortality, independent of other risk factor levels.
在参加多重危险因素干预试验（MRFIT）的12138名冠心病（CHD）高危中年男性中，研究了习惯性休闲时间体力活动（LTPA）对10.5年全因死亡率和死因特异性死亡率的影响。通过明尼苏达问卷确定的LTPA水平与心血管疾病（CVD）、冠心病（CHD）及全因死亡率呈负相关，但与癌症死亡率无关。与处于中间三分位（三分位2）的较活跃男性相比，最不活跃的男性（LTPA三分位1）的CVD、CHD和全因死亡率分别高出22%、27%和15%。额外的LTPA（三分位3）与死亡率的进一步降低无关。比例风险回归分析仅略微减弱了风险差异。本研究支持先前的观察结果，即规律的LTPA与CVD死亡率降低相关，且独立于其他危险因素水平。
