Johdo O, Watanabe Y, Ishikura T, Yoshimoto A, Naganawa H, Sawa T, Takeuchi T
Central Research Laboratories, Mercian Corporation, Fujisawa, Japan.
J Antibiot (Tokyo). 1991 Oct;44(10):1130-40. doi: 10.7164/antibiotics.44.1130.
New anthracycline antibiotics, designated as obelmycins A, D, E, F and G, were isolated from the culture broth of a variant strain of beta-rhodomycin-producing Streptomyces violaceus A262, identified as beta-isorhodomycinone glycosides and gamma-isorhodomycinone glycosides and assayed for their in vitro cytotoxicities against murine leukemic L1210 cell culture and the antimicrobial activities in comparison with some known anthracyclines.
新的蒽环类抗生素，命名为奥贝霉素A、D、E、F和G，是从产β-玫红霉素的紫色链霉菌A262变异菌株的培养液中分离得到的，被鉴定为β-异玫瑰霉素酮糖苷和γ-异玫瑰霉素酮糖苷，并测定了它们对小鼠白血病L1210细胞培养物的体外细胞毒性以及与一些已知蒽环类抗生素相比的抗菌活性。
