Aoki M, Shirai H, Nakayama N, Itezono Y, Mori M, Satoh T, Ohshima S, Watanabe J, Yokose K, Seto H
Nippon Roche Research Center, Kanagawa, Japan.
J Antibiot (Tokyo). 1991 Jun;44(6):635-45. doi: 10.7164/antibiotics.44.635.
Avidinorubicin (MW 1,214, C60H86N4O22) was isolated from the cultured broth of strain NR0576 (which was identified as Streptomyces avidinii Stapley et al.) by butyl alcohol extraction, Sephadex LH-20 column chromatography and preparative HPLC. Avidinorubicin inhibited thrombin-induced platelet aggregation with an IC50 being 7.9 microM and was determined to be a novel anthracycline possessing two units of a new aminosugar, avidinosamine, in place of two decilonitrose groups in decilorubicin.
