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倍频技术与标准自动视野计在高眼压症患者中的应用比较

Frequency Doubling Technology vs Standard Automated Perimetry in Ocular Hypertensive Patients.

作者信息

Giuffrè Italo

机构信息

Medical School, University of Roma "Tor Vergata", Roma, Italy.

出版信息

Open Ophthalmol J. 2009 Mar 24;3:6-9. doi: 10.2174/1874364100903010006.

DOI:10.2174/1874364100903010006
PMID:19554222
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2701324/
Abstract

BACKGROUND

Frequency doubling technology (FDT) perimetry measures contrast sensitivity. The magnocellular component of ganglion cells in human retina is isolated as a whole by the FDT stimulus. The aim of this study is to investigate the role of Humphrey Matrix threshold testing in the detection of early functional retinal impairment in ocular hypertensive patients compared to standard automated perimetry (SAP).

METHODOLOGY

Forty hypertensive patients were enrolled in this longitudinal observational clinical study. Functional testing included randomly Humphrey Matrix perimetry and white-on-white Humphrey visual field perimetry. Ibopamine test was performed in all forty patients. The cut-off of 3 mmHg was considered positive for this provocative test.

RESULTS

Out of 40 patients, we included 21 in ibopamine positive group and 19 in ibopamine negative group. These two groups are sex- and age-matched. In ibopamine positive group the mean increase in IOP is 4.6 mmHg (ranging from 3 to 10 mmHg). Statistics showed that correlation between FDT and SAP was statistically significant in ibopamine negative group and not statistically significant in ibopamine positive group. Only one patient, coming from IBO + group, converted from ocular hypertension to glaucoma. All the other subjects remained stable in both groups without any therapy and visual field abnormalities.

CONCLUSIONS

FDT showed to be more sensitive and specific than SAP mostly in detection of early visual field impairment in ocular hypertensive patients.

摘要

背景

倍频技术（FDT）视野检查可测量对比敏感度。FDT刺激可将人视网膜神经节细胞的大细胞成分作为一个整体分离出来。本研究的目的是比较Humphrey Matrix阈值检查与标准自动视野检查（SAP）在检测高眼压患者早期功能性视网膜损害中的作用。

方法

40例高血压患者纳入了这项纵向观察性临床研究。功能测试包括随机进行的Humphrey Matrix视野检查和白色视标Humphrey视野检查。对所有40例患者进行了异波帕明试验。该激发试验以3 mmHg为阳性临界值。

结果

40例患者中，异波帕明阳性组21例，异波帕明阴性组19例。这两组在性别和年龄上相匹配。异波帕明阳性组眼压平均升高4.6 mmHg（范围为3至10 mmHg）。统计显示，FDT与SAP之间的相关性在异波帕明阴性组具有统计学意义，而在异波帕明阳性组无统计学意义。仅1例来自异波帕明阳性组的患者从高眼压转变为青光眼。两组中所有其他受试者在未接受任何治疗且无视野异常的情况下均保持稳定。

结论

FDT在检测高眼压患者早期视野损害方面比SAP更敏感且更具特异性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e22/2701324/5b536d16ce7e/TOOPHTJ-3-6_F7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e22/2701324/7170f144a24b/TOOPHTJ-3-6_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e22/2701324/6676296ee436/TOOPHTJ-3-6_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e22/2701324/be1c2578ee53/TOOPHTJ-3-6_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e22/2701324/1fc55b3e77db/TOOPHTJ-3-6_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e22/2701324/e89bfda0c9f0/TOOPHTJ-3-6_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e22/2701324/c0e07879766f/TOOPHTJ-3-6_F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e22/2701324/5b536d16ce7e/TOOPHTJ-3-6_F7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e22/2701324/7170f144a24b/TOOPHTJ-3-6_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e22/2701324/6676296ee436/TOOPHTJ-3-6_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e22/2701324/be1c2578ee53/TOOPHTJ-3-6_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e22/2701324/1fc55b3e77db/TOOPHTJ-3-6_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e22/2701324/e89bfda0c9f0/TOOPHTJ-3-6_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e22/2701324/c0e07879766f/TOOPHTJ-3-6_F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e22/2701324/5b536d16ce7e/TOOPHTJ-3-6_F7.jpg

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Br J Ophthalmol. 2008 Dec;92(12):1656-60. doi: 10.1136/bjo.2008.143057. Epub 2008 Oct 1.
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Learning effect of humphrey matrix frequency doubling technology perimetry in patients with ocular hypertension.
J Glaucoma. 2008 Sep;17(6):436-41. doi: 10.1097/IJG.0b013e31815f531d.
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Relationship between Humphrey 30-2 SITA Standard Test, Matrix 30-2 threshold test, and Heidelberg retina tomograph in ocular hypertensive and glaucoma patients.高眼压症和青光眼患者中 Humphrey 30-2 SITA 标准测试、Matrix 30-2 阈值测试与海德堡视网膜断层扫描之间的关系。
J Glaucoma. 2008 Apr-May;17(3):203-10. doi: 10.1097/IJG.0b013e31815a3493.
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Diagnostic accuracy of the Matrix 24-2 and original N-30 frequency-doubling technology tests compared with standard automated perimetry.与标准自动视野计相比，Matrix 24-2和原始N-30倍频技术测试的诊断准确性。
Invest Ophthalmol Vis Sci. 2008 Mar;49(3):954-60. doi: 10.1167/iovs.07-0493.
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Validated prediction model for the development of primary open-angle glaucoma in individuals with ocular hypertension.眼压升高个体原发性开角型青光眼发病的验证预测模型。
Ophthalmology. 2007 Jan;114(1):10-9. doi: 10.1016/j.ophtha.2006.08.031. Epub 2006 Nov 7.
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Topical ocular hypotensive medication and lens opacification: evidence from the ocular hypertension treatment study.局部眼部降压药物与晶状体混浊：来自眼压升高治疗研究的证据。
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Asymmetries and visual field summaries as predictors of glaucoma in the ocular hypertension treatment study.在眼压升高治疗研究中，不对称性和视野摘要作为青光眼的预测指标。
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Validation of a predictive model to estimate the risk of conversion from ocular hypertension to glaucoma.一种用于估计眼压升高发展为青光眼风险的预测模型的验证
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