Ihmsen H, Schraag S, Kreuer S, Bruhn J, Albrecht S
Anästhesiologische Klinik, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Krankenhausstr. 12, 91054, Erlangen.
Anaesthesist. 2009 Jul;58(7):708-15. doi: 10.1007/s00101-009-1575-3.
Since its commercial introduction in 1996, target-controlled infusion (TCI) has become an established technique for administration of intravenous anaesthetics. Modern TCI systems, however, are characterized by an increasing number of additional options and features, such as the choice between different pharmacokinetic models and modes of application, which may confuse the less experienced user. This review describes the differences between pharmacokinetic models, modes of application and the effect of covariates as well as the consequences for dosing. The aim is to explicate for the user of modern TCI systems the underlying scientific concepts and the relevance for clinical practice.
自1996年商业化推出以来，靶控输注（TCI）已成为静脉麻醉药给药的一项成熟技术。然而，现代TCI系统的特点是附加选项和功能越来越多，例如不同药代动力学模型和应用模式之间的选择，这可能会让经验不足的用户感到困惑。这篇综述描述了药代动力学模型、应用模式和协变量的影响之间的差异以及给药的后果。目的是向现代TCI系统的用户阐明潜在的科学概念及其与临床实践的相关性。
