通过释放 NO 实现光诱导杀菌效应的基于 pHEMA 的水凝胶的特性。
Characterization of pHEMA-based hydrogels that exhibit light-induced bactericidal effect via release of NO.
机构信息
Department of Chemistry and Biochemistry, University of California at Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA.
出版信息
J Mater Sci Mater Med. 2009 Nov;20(11):2353-60. doi: 10.1007/s10856-009-3795-0. Epub 2009 Jun 24.
Abstract
A light-activated NO donor, [Mn(PaPy(3))(NO)]ClO(4) (1a), has been incorporated into HEMA-based polymer hydrogel and the nitrosyl-polymer conjugate materials 1a(x) · HG and 1a(x) · HG(MB) have been characterized. The NO releasing properties and antibacterial capabilities of these materials in conjunction with growth attenuators such as hydrogen peroxide and methylene blue (MB) are reported. Since the nitrosyl releases NO only upon exposure to light, materials like 1a(x) · HG(MB) could be used as wound dressings that deliver NO under controlled conditions.
摘要
一种光激活的一氧化氮供体[Mn(PaPy(3))(NO)]ClO(4)（1a）已被掺入到 HEMA 基聚合物水凝胶中，并且已经对亚硝酰聚合物缀合物材料 1a(x)·HG 和 1a(x)·HG(MB)进行了表征。报道了这些材料的一氧化氮释放特性和抗菌能力，以及与过氧化氢和亚甲基蓝（MB）等生长抑制剂的协同作用。由于只有在暴露于光下时，亚硝酰才会释放一氧化氮，因此像 1a(x)·HG(MB)这样的材料可以用作在受控条件下释放一氧化氮的伤口敷料。
相似文献
1
Characterization of pHEMA-based hydrogels that exhibit light-induced bactericidal effect via release of NO.
J Mater Sci Mater Med. 2009 Nov;20(11):2353-60. doi: 10.1007/s10856-009-3795-0. Epub 2009 Jun 24.
2
A transparent wound dressing based on bacterial cellulose whisker and poly(2-hydroxyethyl methacrylate).
Int J Biol Macromol. 2017 Dec;105(Pt 1):638-644. doi: 10.1016/j.ijbiomac.2017.07.075. Epub 2017 Jul 14.
3
Incorporation of a designed ruthenium nitrosyl in PolyHEMA hydrogel and light-activated delivery of NO to myoglobin.
Inorg Chem. 2007 Aug 6;46(16):6601-6. doi: 10.1021/ic700694b. Epub 2007 Jul 6.
4
A Ruthenium Nitrosyl-Functionalized Magnetic Nanoplatform with Near-Infrared Light-Controlled Nitric Oxide Delivery and Photothermal Effect for Enhanced Antitumor and Antibacterial Therapy.
ACS Appl Mater Interfaces. 2020 Jan 8;12(1):312-321. doi: 10.1021/acsami.9b18865. Epub 2019 Dec 30.
5
About the effect of eye blinking on drug release from pHEMA-based hydrogels: an in vitro study.
J Biomater Sci Polym Ed. 2015;26(4):235-51. doi: 10.1080/09205063.2014.994948. Epub 2015 Jan 2.
6
pHEMA@AGMNA-1: A novel material for the development of antibacterial contact lens.
Mater Sci Eng C Mater Biol Appl. 2020 Jun;111:110770. doi: 10.1016/j.msec.2020.110770. Epub 2020 Feb 24.
7
Comparison of two hydrogel formulations for drug release in ophthalmic lenses.
J Biomed Mater Res B Appl Biomater. 2014 Aug;102(6):1170-80. doi: 10.1002/jbm.b.33099. Epub 2014 Jan 10.
8
Biodegradation of poly(2-hydroxyethyl methacrylate) (PHEMA) and poly{(2-hydroxyethyl methacrylate)-co-[poly(ethylene glycol) methyl ether methacrylate]} hydrogels containing peptide-based cross-linking agents.
Biomacromolecules. 2010 Nov 8;11(11):2949-59. doi: 10.1021/bm100756c. Epub 2010 Oct 20.
9
Mechano-Responsive, Tough, and Antibacterial Zwitterionic Hydrogels with Controllable Drug Release for Wound Healing Applications.
ACS Appl Mater Interfaces. 2020 Nov 25;12(47):52307-52318. doi: 10.1021/acsami.0c13009. Epub 2020 Nov 12.
10
Drug loading optimization and extended drug delivery of corticoids from pHEMA based soft contact lenses hydrogels via chemical and microstructural modifications.
Int J Pharm. 2015 Jun 20;487(1-2):260-9. doi: 10.1016/j.ijpharm.2015.04.037. Epub 2015 Apr 17.
引用本文的文献
1
Opportunities for Nitric Oxide in Potentiating Cancer Immunotherapy.
Pharmacol Rev. 2022 Oct;74(4):1146-1175. doi: 10.1124/pharmrev.121.000500.
2
Recent Advances in Hydrogel-Mediated Nitric Oxide Delivery Systems Targeted for Wound Healing Applications.
Pharmaceutics. 2022 Jun 29;14(7):1377. doi: 10.3390/pharmaceutics14071377.
3
pHEMA: An Overview for Biomedical Applications.
Int J Mol Sci. 2021 Jun 15;22(12):6376. doi: 10.3390/ijms22126376.
4
Synthetic, Natural, and Semisynthetic Polymer Carriers for Controlled Nitric Oxide Release in Dermal Applications: A Review.
Polymers (Basel). 2021 Feb 28;13(5):760. doi: 10.3390/polym13050760.
5
The evolving landscape for cellular nitric oxide and hydrogen sulfide delivery systems: A new era of customized medications.
Biochem Pharmacol. 2020 Jun;176:113931. doi: 10.1016/j.bcp.2020.113931. Epub 2020 Mar 26.
6
Providing Antibacterial Activity to Poly(2-Hydroxy Ethyl Methacrylate) by Copolymerization with a Methacrylic Thiazolium Derivative.
Int J Mol Sci. 2018 Dec 19;19(12):4120. doi: 10.3390/ijms19124120.
7
Antibacterial Hydrogels.
Adv Sci (Weinh). 2018 Feb 22;5(5):1700527. doi: 10.1002/advs.201700527. eCollection 2018 May.
8
Antimicrobial hydrogels: promising materials for medical application.
Int J Nanomedicine. 2018 Apr 12;13:2217-2263. doi: 10.2147/IJN.S154748. eCollection 2018.
9
Advances in the Fabrication of Antimicrobial Hydrogels for Biomedical Applications.
Materials (Basel). 2017 Feb 26;10(3):232. doi: 10.3390/ma10030232.
10
Polymer-Based Nitric Oxide Therapies: Recent Insights for Biomedical Applications.
Adv Funct Mater. 2012 Jan 25;22(2):239-260. doi: 10.1002/adfm.201101707.
本文引用的文献
1
PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release.
Science. 2008 Nov 28;322(5906):1392-5. doi: 10.1126/science.1164571.
2
Sensitization of ruthenium nitrosyls to visible light via direct coordination of the dye resorufin: trackable NO donors for light-triggered NO delivery to cellular targets.
J Am Chem Soc. 2008 Jul 9;130(27):8834-46. doi: 10.1021/ja801823f.
3
Near-infrared light activated release of nitric oxide from designed photoactive manganese nitrosyls: strategy, design, and potential as NO donors.
J Am Chem Soc. 2008 Apr 2;130(13):4447-58. doi: 10.1021/ja710265j. Epub 2008 Mar 12.
4
Incorporation of a designed ruthenium nitrosyl in PolyHEMA hydrogel and light-activated delivery of NO to myoglobin.
Inorg Chem. 2007 Aug 6;46(16):6601-6. doi: 10.1021/ic700694b. Epub 2007 Jul 6.
5
Community-acquired methicillin-resistant Staphylococcus aureus (MRSA): new issues for infection control.
Int J Antimicrob Agents. 2007 Sep;30(3):210-2. doi: 10.1016/j.ijantimicag.2007.04.003. Epub 2007 Jun 12.
6
A new approach for studying fast biological reactions involving nitric oxide: generation of NO using photolabile ruthenium and manganese NO donors.
Photochem Photobiol. 2006 Sep-Oct;82(5):1377-84. doi: 10.1562/2006-07-25-rc-984.
7
Biological activity of designed photolabile metal nitrosyls: light-dependent activation of soluble guanylate cyclase and vasorelaxant properties in rat aorta.
J Med Chem. 2006 Dec 14;49(25):7325-30. doi: 10.1021/jm0604629.
8
Phenothiazinium derivatives for pathogen inactivation in blood products.
J Photochem Photobiol B. 2007 Jan 3;86(1):45-58. doi: 10.1016/j.jphotobiol.2006.07.005. Epub 2006 Sep 18.
9
Methylene blue implicated in potentially fatal serotonin toxicity.
Anaesthesia. 2006 Oct;61(10):1013-4. doi: 10.1111/j.1365-2044.2006.04808.x.
10
Reducing implant-related infections: active release strategies.
Chem Soc Rev. 2006 Sep;35(9):780-9. doi: 10.1039/b515219b. Epub 2006 May 5.
Zotero 插件