Center for Nanotechnology and Sustainability, Department of Mechanical Engineering, National University of Singapore, Singapore 117581, Singapore.
Institute of Polymers, Composites and Biomaterials-National Research Council (IPCB-CNR), Viale J.F. Kennedy 54-Mostra d'Oltremare pad. 20, 80125 Naples, Italy.
Int J Mol Sci. 2021 Jun 15;22(12):6376. doi: 10.3390/ijms22126376.
Poly(2-hydroxyethyl methacrylate) (pHEMA) as a biomaterial with excellent biocompatibility and cytocompatibility elicits a minimal immunological response from host tissue making it desirable for different biomedical applications. This article seeks to provide an in-depth overview of the properties and biomedical applications of pHEMA for bone tissue regeneration, wound healing, cancer therapy (stimuli and non-stimuli responsive systems), and ophthalmic applications (contact lenses and ocular drug delivery). As this polymer has been widely applied in ophthalmic applications, a specific consideration has been devoted to this field. Pure pHEMA does not possess antimicrobial properties and the site where the biomedical device is employed may be susceptible to microbial infections. Therefore, antimicrobial strategies such as the use of silver nanoparticles, antibiotics, and antimicrobial agents can be utilized to protect against infections. Therefore, the antimicrobial strategies besides the drug delivery applications of pHEMA were covered. With continuous research and advancement in science and technology, the outlook of pHEMA is promising as it will most certainly be utilized in more biomedical applications in the near future. The aim of this review was to bring together state-of-the-art research on pHEMA and their applications.
聚（2-羟乙基甲基丙烯酸酯）（pHEMA）作为一种具有优异生物相容性和细胞相容性的生物材料，从宿主组织中引发最小的免疫反应，使其成为各种生物医学应用的理想选择。本文旨在深入概述 pHEMA 在骨组织再生、伤口愈合、癌症治疗（刺激和非刺激响应系统）以及眼科应用（隐形眼镜和眼用药物输送）中的特性和生物医学应用。由于该聚合物已广泛应用于眼科应用，因此专门考虑了这一领域。纯 pHEMA 没有抗菌性能，并且生物医学器械所在的部位可能容易受到微生物感染。因此，可以使用抗菌策略，如使用银纳米粒子、抗生素和抗菌剂来预防感染。因此，除了 pHEMA 的药物输送应用之外，还涵盖了抗菌策略。随着科学技术的不断研究和进步，pHEMA 的前景一片光明，因为它肯定会在不久的将来在更多的生物医学应用中得到利用。本文的目的是汇集关于 pHEMA 及其应用的最新研究。
