Bilak Amber, Su Tin Tin
MCD Biology, University of Colorado, Boulder, CO 80309-0347, USA.
Apoptosis. 2009 Aug;14(8):943-9. doi: 10.1007/s10495-009-0374-2.
Key decisions one makes in a lifetime include whether and how often to reproduce, what role to play in the community and, under certain conditions, whether to live or die. Similar decisions are also made at the level of cells: whether to divide, what fate to assume in the multicellular context of metazoan development and, under certain conditions, whether to live or to die. The pro-apoptotic gene hid plays an important role in the execution of cell death in Drosophila. Here, we review the various levels of control that exist to regulate Hid according to the life-or-death choice of a cell.
一个人一生中做出的关键决定包括是否以及多久繁殖一次、在社会中扮演什么角色,以及在某些情况下是生还是死。细胞层面也会做出类似的决定:是否分裂、在多细胞后生动物发育的背景下承担何种命运,以及在某些情况下是生还是死。促凋亡基因hid在果蝇细胞死亡的执行过程中起着重要作用。在这里,我们根据细胞的生死抉择来综述调控hid的各种控制水平。