阿扑吗啡对猫瞬膜交感神经传递的影响。

Influence of apomorphine on sympathetic neural transmission in the nictitating membrane of the cat.

作者信息

György L, Dóda M

出版信息

Arch Int Pharmacodyn Ther. 1977 Apr;226(2):194-204.

Abstract

Apomorphine inhibited the nictitating membrane contractions elicited by pre- or postganglionic stimulation of the cervical sympathetic nerve but did not influence even in higher doses the effect of noradrenaline and adrenaline on this organ. The inhibition evoked by apomorphine could be antagonized by haloperidol but was not influenced by phentolamine and propranolol. Dopamine and noradrenaline inhibited the nictitating membrane contractions elicited by nerve stimulation, but clonidine was ineffective in our experiments. Haloperidol antagonized the inhibition evoked by dopamine but did not influence the similar effect of noradrenaline.

摘要

阿扑吗啡抑制颈交感神经节前或节后刺激所引起的瞬膜收缩，但即使大剂量时也不影响去甲肾上腺素和肾上腺素对该器官的作用。阿扑吗啡所引起的抑制作用可被氟哌啶醇拮抗，但不受酚妥拉明和普萘洛尔影响。多巴胺和去甲肾上腺素抑制神经刺激所引起的瞬膜收缩，但可乐定在我们的实验中无效。氟哌啶醇拮抗多巴胺所引起的抑制作用，但不影响去甲肾上腺素的类似作用。

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