肾上腺素能神经元阻滞在普萘洛尔降压作用中的作用
Role of adrenergic neurone blockade in the hypotensive action of propranolol.
作者信息
Eliash S, Weinstock M
出版信息
Br J Pharmacol. 1971 Oct;43(2):287-94.
Abstract
- Propranolol, in doses of 25-100 mug/kg, blocks contractions of the nictitating membrane to nerve stimulation but not to injected noradrenaline.2. This adrenergic neurone blocking action of propranolol is antagonized by amphetamine.3. It is also reversed by raising the dose of propranolol to amounts exceeding 0.5 mg/kg.4. Still larger amounts potentiate the responses of the nictitating membrane to both submaximal stimulation of the cervical sympathetic nerve and to injected noradrenaline.5. The (+) isomer of propranolol produced adrenergic nerve blockade and some degree of hypotension without blocking cardiac beta-adrenoceptors.6. The relevance of adrenergic neurone blockade to the hypotensive effect of propranolol is discussed.
摘要
普萘洛尔剂量为25 - 100微克/千克时，可阻断神经刺激引起的瞬膜收缩，但不阻断注射去甲肾上腺素引起的收缩。
普萘洛尔的这种肾上腺素能神经元阻断作用可被苯丙胺拮抗。
将普萘洛尔剂量增至超过0.5毫克/千克时，此作用也会被逆转。
更大剂量可增强瞬膜对颈交感神经次最大刺激以及对注射去甲肾上腺素的反应。
普萘洛尔的（+）异构体产生肾上腺素能神经阻滞和一定程度的低血压，而不阻断心脏β - 肾上腺素能受体。
讨论了肾上腺素能神经元阻断与普萘洛尔降压作用的相关性。
相似文献
1
Role of adrenergic neurone blockade in the hypotensive action of propranolol.肾上腺素能神经元阻滞在普萘洛尔降压作用中的作用
Br J Pharmacol. 1971 Oct;43(2):287-94.
2
Factors influencing the adrenergic neurone blocking action of propranolol.影响普萘洛尔肾上腺素能神经元阻滞作用的因素。
Br J Pharmacol. 1972 Aug;45(4):630-4. doi: 10.1111/j.1476-5381.1972.tb08120.x.
3
The effect of propranolol on vascular responses to sympathetic nerve stimulation.普萘洛尔对血管对交感神经刺激反应的影响。
Br J Pharmacol. 1975 Apr;53(4):517-24. doi: 10.1111/j.1476-5381.1975.tb07389.x.
4
5
Comparison of bretylium and guanethidine: tolerance, and effects on adrenergic nerve function and responses to sympathomimetic amines.溴苄铵与胍乙啶的比较：耐受性以及对肾上腺素能神经功能和对拟交感胺反应的影响。
Br J Pharmacol Chemother. 1962 Aug;19(1):13-41. doi: 10.1111/j.1476-5381.1962.tb01424.x.
6
Influence of apomorphine on sympathetic neural transmission in the nictitating membrane of the cat.阿扑吗啡对猫瞬膜交感神经传递的影响。
Arch Int Pharmacodyn Ther. 1977 Apr;226(2):194-204.
7
The relation between the adrenergic neurone-blocking and noradrenaline-depleting actions of some guanidine derivatives.某些胍衍生物的肾上腺素能神经元阻断作用与去甲肾上腺素耗竭作用之间的关系。
Br J Pharmacol. 1974 Jun;51(2):237-47. doi: 10.1111/j.1476-5381.1974.tb09653.x.
8
The effects of beta-adrenergic receptor blockade on the blood pressure and heart rate changes induced by noradrenaline infusion and postinfusional hypotension.β-肾上腺素能受体阻滞剂对去甲肾上腺素输注引起的血压和心率变化以及输注后低血压的影响。
Arch Int Pharmacodyn Ther. 1968 Jan;171(1):136-58.
9
Adrenergic transmission failure via the blockade of presynaptic beta receptors in guinea-pig pulmonary arteries.通过阻断豚鼠肺动脉突触前β受体导致肾上腺素能传递失败。
J Pharmacol Exp Ther. 1981 Jul;218(1):242-7.
10
A further study of the antagonistic action between alpha and beta blocking agents.α和β阻滞剂之间拮抗作用的进一步研究。
Proc West Pharmacol Soc. 1968;11:73-4.
引用本文的文献
1
Response of blood pressure and plasma norepinephrine to propranolol, metoprolol and clonidine during isometric and dynamic exercise in hypertensive patients.高血压患者在等长运动和动态运动期间血压及血浆去甲肾上腺素对普萘洛尔、美托洛尔和可乐定的反应。
Eur J Clin Pharmacol. 1982;21(4):275-9. doi: 10.1007/BF00637613.
2
The effects of (+)- and (-)-propranolol on 3H-transmitter efflux in guinea-pig atria and the presynaptic beta-adrenoceptor hypothesis.（+）-和（-）-普萘洛尔对豚鼠心房3H递质外流的影响及突触前β-肾上腺素能受体假说
Br J Pharmacol. 1980 Nov;70(3):491-8. doi: 10.1111/j.1476-5381.1980.tb08728.x.
3
Influence of beta-adrenoceptor blocking agents on the turnover rate of cardiac and splenic noradrenaline in rats.β-肾上腺素能受体阻断剂对大鼠心脏和脾脏去甲肾上腺素周转率的影响。
Br J Pharmacol. 1980 May;69(1):35-40. doi: 10.1111/j.1476-5381.1980.tb10880.x.
4
Beta-adrenoceptor antagonists: studies on behaviour (delayed differentiation) in the monkey (Macaca mulatta).β-肾上腺素能受体拮抗剂：对猕猴（恒河猴）行为（延迟分化）的研究。
Br J Pharmacol. 1980 Jan;68(1):75-82. doi: 10.1111/j.1476-5381.1980.tb10701.x.
5
R-enantiomer of timolol: a potential selective ocular antihypertensive agent.噻吗洛尔的R-对映体：一种潜在的选择性眼部抗高血压药物。
Graefes Arch Clin Exp Ophthalmol. 1984;221(5):234-8. doi: 10.1007/BF02134145.
6
Factors influencing the adrenergic neurone blocking action of propranolol.影响普萘洛尔肾上腺素能神经元阻滞作用的因素。
Br J Pharmacol. 1972 Aug;45(4):630-4. doi: 10.1111/j.1476-5381.1972.tb08120.x.
7
The influence of propranolol on abnormal behaviour induced in rats by prolonged isolation--an animal model for mania?普萘洛尔对长期隔离诱导的大鼠异常行为的影响——一种躁狂症的动物模型？
Br J Pharmacol. 1973 Jun;48(2):348P-349P.
8
Effect of propranolol on the blood pressure of normotensive and pinealectomized hypertensive rats.普萘洛尔对正常血压和松果体切除的高血压大鼠血压的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1974;281(1):1-12. doi: 10.1007/BF00500609.
9
The effect of dl-propranolol, d-propranolol and practolol on the hyperactivity induced in rats by prolonged isolation.dl-普萘洛尔、d-普萘洛尔和美多心安对长期隔离诱导大鼠产生的多动行为的影响。
Psychopharmacologia. 1973 Jun 19;30(3):241-50. doi: 10.1007/BF00422870.
10
Long term treatment of moderate hypertension with the beta1-receptor blocking agent metoprolol. II. Effect of submaximal work and insulin-induced hypoglycaemia on plasma catecholamines and renin activity, blood pressure and pulse rate.使用β1受体阻滞剂美托洛尔对中度高血压进行长期治疗。II. 次极量运动和胰岛素诱导的低血糖对血浆儿茶酚胺、肾素活性、血压和脉搏率的影响。
Eur J Clin Pharmacol. 1977 Apr 20;11(4):247-54. doi: 10.1007/BF00607672.
本文引用的文献
1
INTERACTION OF GUANETHIDINE WITH ADRENERGIC NEURONS.胍乙啶与肾上腺素能神经元的相互作用。
J Pharmacol Exp Ther. 1965 Mar;147:303-12.
2
Evaluation of the hypotensive effect of beta-adrenergic blockade in hypertension.β-肾上腺素能阻滞剂对高血压降压作用的评估。
Acta Med Scand. 1969 May;185(5):443-8. doi: 10.1111/j.0954-6820.1969.tb07362.x.
3
Treatment of hypertension with propranolol.用普萘洛尔治疗高血压。
Br Med J. 1969 Jan 4;1(5635):7-16. doi: 10.1136/bmj.1.5635.7.
4
A comparison of some cardiovascular properties of propranolol, MJ 1999 and quinidine in relation to their effects in hypertensive animals.普萘洛尔、MJ 1999和奎尼丁的某些心血管特性与其对高血压动物作用的比较。
Br J Pharmacol. 1968 Sep;34(1):116-26. doi: 10.1111/j.1476-5381.1968.tb07955.x.
5
The paradox of beta-adrenergic blockade in hypertension.高血压中β-肾上腺素能阻滞剂的悖论。
Circulation. 1968 Mar;37(3):417-23. doi: 10.1161/01.cir.37.3.417.
6
Controlled trial of propranolol in hypertension.普萘洛尔治疗高血压的对照试验。
Br Med J. 1970 Feb 21;1(5694):471-4. doi: 10.1136/bmj.1.5694.471.
7
Adrenergic neuron blocking properties of (plus or minus)-propranolol and (plus)-propranolol.（±）-普萘洛尔和（+）-普萘洛尔的肾上腺素能神经元阻断特性。
J Pharm Pharmacol. 1970 Nov;22(11):806-10. doi: 10.1111/j.2042-7158.1970.tb08443.x.
8
Prejunctional actions of some beta-adrenoreceptor antagonists in the vas deferens preparation of the guinea-pig.某些β-肾上腺素能受体拮抗剂在豚鼠输精管制备中的节前作用。
Br J Pharmacol. 1970 May;39(1):128-38. doi: 10.1111/j.1476-5381.1970.tb09562.x.
9
Sympathetic involvement in vagal escape and the effects of beta-receptor blocking drugs.交感神经参与迷走神经逸搏及β受体阻滞剂的作用。
Eur J Pharmacol. 1969 Oct;8(1):47-57. doi: 10.1016/0014-2999(69)90128-9.
10
An adrenergic neuron blocking action of propranolol in isolated tissues.普萘洛尔在离体组织中的肾上腺素能神经元阻断作用。
J Pharm Pharmacol. 1968 Dec;20:Suppl:130S+. doi: 10.1111/j.2042-7158.1968.tb09874.x.
Zotero 插件