Trost Barry M, Sieber Joshua D, Qian Wei, Dhawan Rajiv, Ball Zachary T
Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
Angew Chem Int Ed Engl. 2009;48(30):5478-81. doi: 10.1002/anie.200901907.
The alkyne functional group can be a valuable handle for organic synthesis since the alkyne can function both as a nucleophile or as an electrophile when activated with an appropriate metal catalyst. Herein, we exploit this dual nature of the alkyne moiety for the concise total synthesis of the natural product soraphen A.
炔基官能团对于有机合成而言可能是一个有价值的切入点，因为在合适的金属催化剂作用下，炔烃既可以作为亲核试剂，也可以作为亲电试剂发挥作用。在此，我们利用炔烃部分的这种双重性质，对天然产物索拉芬A进行简洁的全合成。
