过渡金属催化合成aspergillide B：炔烃加成策略。
Transition-metal-catalyzed synthesis of aspergillide B: an alkyne addition strategy.
机构信息
Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA.
出版信息
Org Lett. 2012 Mar 2;14(5):1322-5. doi: 10.1021/ol300200m. Epub 2012 Feb 22.
Abstract
A catalytic enantioselective formal total synthesis of aspergillide B is reported. This linchpin synthesis was enabled by the development of new conditions for Zn-ProPhenol catalyzed asymmetric alkyne addition. This reaction was used in conjunction with ruthenium-catalyzed trans-hydrosilylation to affect the rapid construction of a late-stage synthetic intermediate of aspergillide B to complete a formal synthesis of aspergillide B in a highly efficient manner.
摘要
报道了一种催化对映选择性的 Aspergillide B 全合成方法。这一关键合成的实现得益于 Zn-ProPhenol 催化的不对称炔加成反应新条件的发展。该反应与钌催化的反式硅氢化反应结合使用，可快速构建 Aspergillide B 的晚期合成中间体，以高效的方式完成 Aspergillide B 的全合成。
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