Okpara Nnenna, Aswad Bassam, Baffy Gyorgy
Department of Medicine, Division of Gastroenterology, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, MA 02130, United States.
World J Gastroenterol. 2009 Jun 28;15(24):2975-9. doi: 10.3748/wjg.15.2975.
Eosinophilic colitis (EC) is a rare form of primary eosinophilic gastrointestinal disease with a bimodal peak of prevalence in neonates and young adults. EC remains a little understood condition in contrast to the increasingly recognized eosinophilic esophagitis. Clinical presentation of EC is highly variable according to mucosal, transmural, or serosal predominance of inflammation. EC has a broad differential diagnosis because colon tissue eosinophilia often occurs in parasitic infection, drug-induced allergic reactions, inflammatory bowel disease, and various connective tissue disorders, which require thorough searching for secondary causes that may be specifically treated with antibiotics or dietary and drug elimination. Like eosinophilic gastrointestinal disease involving other segments of the gastrointestinal tract, EC responds very well to steroids that may be spared by using antihistamines, leukotriene inhibitors and biologics.
嗜酸性粒细胞性结肠炎（EC）是一种罕见的原发性嗜酸性粒细胞性胃肠疾病，在新生儿和年轻人中患病率呈双峰高峰。与日益被认识的嗜酸性粒细胞性食管炎相比，EC仍然是一种了解甚少的疾病。根据炎症在黏膜、透壁或浆膜的优势情况，EC的临床表现差异很大。EC的鉴别诊断范围广泛，因为结肠组织嗜酸性粒细胞增多常发生在寄生虫感染、药物引起的过敏反应、炎症性肠病和各种结缔组织疾病中，这需要彻底寻找可能通过抗生素或饮食及药物排除进行特异性治疗的继发原因。与涉及胃肠道其他节段的嗜酸性粒细胞性胃肠疾病一样，EC对类固醇反应非常好，使用抗组胺药、白三烯抑制剂和生物制剂可能会减少类固醇的使用。
