El-Fiky S, Ismail A A
Arch Geschwulstforsch. 1977;47(2):138-44.
Enzymological studies of succinic dehydrogenase and cytochrome oxidase were made on human squamous cell carcinoma of the cervix uteri before, during and after radiation therapy by radium and 60CO. The enzymatic activities of the two enzymes were higher in cells of stage III than in the corresponding cells of stage II. In addition, after treatment, no enzymatic activity could be detected. These changes may be explained on the basis of mitochondrial damage as a result of radiation effect.
采用镭和钴60对子宫颈鳞状细胞癌患者进行放射治疗，分别在放疗前、放疗期间和放疗后，对琥珀酸脱氢酶和细胞色素氧化酶进行了酶学研究。Ⅲ期细胞中这两种酶的酶活性高于Ⅱ期相应细胞。此外，治疗后未检测到酶活性。这些变化可能是由于辐射效应导致线粒体损伤所致。
