Higashimura Yukie, Shimoju Rie, Maruyama Hitoshi, Kurosawa Mieko
Center for Medical Science, International University of Health and Welfare, Otawara, Tochigi, Japan.
Auton Neurosci. 2009 Oct 5;150(1-2):100-3. doi: 10.1016/j.autneu.2009.06.003. Epub 2009 Jun 24.
The effects of electro-acupuncture (EA) on plasma concentration of glucose and on responsiveness to insulin were examined in an animal model of diabetes, the streptozotocin-treated rat. Two weeks after treatment with streptozotocin, rats were anesthetized with urethane-chloralose and subjected to the EA for 10 min delivered to the tibialis anterior muscle of one side. The stimulation produced no significant changes in plasma glucose concentration. In contrast, EA increased the response of plasma glucose to insulin (0.2 U kg(-1)). The effect of EA on the responsiveness to insulin was abolished by section of both sciatic and femoral nerves ipsilateral to the side of the EA. These results show that EA in diabetic rats has no effect on plasma glucose concentration while it augments the responsiveness to insulin, and we show that this occurs via a mechanism that involves the somatic afferent nerves.
在糖尿病动物模型链脲佐菌素处理的大鼠中，研究了电针（EA）对血浆葡萄糖浓度和胰岛素反应性的影响。用链脲佐菌素治疗两周后，大鼠用乌拉坦-氯醛糖麻醉，并对一侧胫骨前肌进行10分钟的电针治疗。刺激未引起血浆葡萄糖浓度的显著变化。相比之下，电针增强了血浆葡萄糖对胰岛素（0.2 U kg(-1)）的反应。双侧切断电针侧同侧的坐骨神经和股神经后，电针增强胰岛素反应性的作用消失。这些结果表明，糖尿病大鼠的电针治疗对血浆葡萄糖浓度没有影响，但增强了对胰岛素的反应性，并且我们发现这是通过一种涉及躯体传入神经的机制发生的。
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