Fritsma G A, Leikin J B, Maturen A J, Froelich C J, Hryhorczuk D O
Hematology Business Center, Baxter Diagnostics Incorporated, McGaw Park, Illinois.
J Emerg Med. 1991;9 Suppl 1:37-43. doi: 10.1016/0736-4679(91)90586-5.
Anticardiolipin antibody, an immunoglobulin that binds negatively charged phospholipids, is considered to be an in vitro inhibitor of clot-based coagulation procedures. We adapted an enzyme immunoassay using stationary cardiolipin antigen to compare anticardiolipin antibody activity in the plasma of 44 cocaine abusers with its activity in the serum of 72 blood donors and a sample of 203 random specimens from healthy volunteers. Activity of 20 of the 44 abusers and 43 of 203 random specimens exceeded the donor control reference range. Patients using intravenous cocaine were more likely to have elevated activity than those who inhaled (P less than 0.05). Of 7 patients who had seizures or thromboembolic disorders, 5 were anticardiolipin antibody positive. Enzyme immunoassay may have predictive value for ischemic disease in cocaine abusers.
抗心磷脂抗体是一种能与带负电荷磷脂结合的免疫球蛋白，被认为是基于凝血块的凝血程序的体外抑制剂。我们采用固定化心磷脂抗原的酶免疫测定法，比较了44名可卡因滥用者血浆中的抗心磷脂抗体活性与其在72名献血者血清中的活性，以及来自健康志愿者的203份随机样本中的活性。44名滥用者中有20名以及203份随机样本中有43份的活性超过了献血者对照参考范围。使用静脉注射可卡因的患者比吸入可卡因的患者更有可能出现活性升高（P小于0.05）。在7名患有癫痫或血栓栓塞性疾病的患者中，有5名抗心磷脂抗体呈阳性。酶免疫测定法可能对可卡因滥用者的缺血性疾病具有预测价值。
