Chakravarty K K, Gray R E, Webley M, Byron M A, Wozniak J
Oxford Regional Rheumatic Disease Research Centre, Aylesbury, Buckinghamshire, UK.
Postgrad Med J. 1991 Apr;67(786):358-61. doi: 10.1136/pgmj.67.786.358.
In a cross-sectional study of 100 healthy elderly individuals, anticardiolipin antibodies (aCL) were measured using an ELISA technique. aCL were not detected in the majority of subjects (63%), and in the remaining 37% titres were within the laboratory reference range (mean +5 standard deviations) previously determined for adults of all ages. In contrast, significant titres of IgM rheumatoid factor were found in 10%, antimitochondrial antibody in 13%, antinuclear factor in 5%, anti-smooth muscle antibody in 18%, antiparietal cell antibody in 10%, and antireticulin antibody in 1%. Antibodies to single or double-stranded DNA were not detected in any subject. We conclude that, although other auto-antibodies may be present in the healthy aging population in Britain, abnormally elevated levels of aCL antibody do not occur, and when present may be an indicator of autoimmune-mediated pathology.
在一项针对100名健康老年人的横断面研究中，采用酶联免疫吸附测定（ELISA）技术检测了抗心磷脂抗体（aCL）。大多数受试者（63%）未检测到aCL，其余37%的受试者其抗体滴度在先前为所有年龄段成年人确定的实验室参考范围（均值+5个标准差）内。相比之下，10%的受试者检测到显著滴度的IgM类风湿因子，13%的受试者检测到抗线粒体抗体，5%的受试者检测到抗核因子，18%的受试者检测到抗平滑肌抗体，10%的受试者检测到抗壁细胞抗体，1%的受试者检测到抗网硬蛋白抗体。任何受试者均未检测到抗单链或双链DNA抗体。我们得出结论，尽管英国健康老龄化人群中可能存在其他自身抗体，但aCL抗体水平不会异常升高，若出现则可能是自身免疫介导病理的一个指标。
