Barton Gregory M, Kagan Jonathan C
Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720-3200, USA.
Nat Rev Immunol. 2009 Aug;9(8):535-42. doi: 10.1038/nri2587. Epub 2009 Jun 26.
An emerging paradigm in innate immune signalling is that cell biological context can influence the outcome of a ligand-receptor interaction. In this Review we discuss how Toll-like receptor (TLR) activation and signal transduction are regulated by subcellular compartmentalization of receptors and downstream signalling components. In particular, we focus on the functional specialization of TLRs in the endosomal system. We discuss recent studies that illustrate how basic aspects of the cellular machinery contribute to TLR function and regulation. This emerging area of research will provide important information on how immune signal transduction networks depend on (and in some cases influence) the generic regulators that organize eukaryotic cells.
先天免疫信号传导中一个新出现的范例是，细胞生物学背景可以影响配体-受体相互作用的结果。在本综述中，我们讨论了Toll样受体（TLR）的激活和信号转导如何受到受体和下游信号成分的亚细胞区室化的调节。特别是，我们关注内体系统中TLR的功能特化。我们讨论了最近的研究，这些研究说明了细胞机制的基本方面如何有助于TLR的功能和调节。这个新兴的研究领域将提供重要信息，说明免疫信号转导网络如何依赖于（在某些情况下还会影响）组织真核细胞的通用调节因子。
