Aziz Natali, Cheng Yvonne W, Caughey Aaron B
Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA.
J Matern Fetal Neonatal Med. 2009 Sep;22(9):780-4. doi: 10.3109/14767050902922581.
To examine the outcomes of neonates born to women with chorioamnionitis in the setting of preterm premature rupture of membranes (PPROM).
A retrospective cohort study was conducted of deliveries with diagnosis of PPROM between 24 and 34 weeks of gestation at an academic medical center. Patients who delivered with the diagnosis of clinical chorioamnionitis were compared with patients who delivered without this diagnosis. Neonatal outcomes including Apgar scores, intracranial hemorrhage (ICH), sepsis, pneumonia, respiratory distress syndrome (RDS), and necrotizing enterocolitis (NEC) were assessed. Dichotomous outcomes were compared using chi-square test. Multivariable regression analyses were performed to control for potential confounding variables.
Of the 1153 patients diagnosed with PPROM, 29.0% were diagnosed with chorioamnionitis prior to delivery. Neonates born to mothers with a diagnosis of chorioamnionitis in the setting of PPROM had higher incidences (34.8%) of low 5-min Apgar scores, RDS, NEC, ICH, and pneumonia compared with 22.9% in neonates born to mothers without chorioamnionitis (p < 0.001).
Patients who develop chorioamnionitis in the setting of PPROM are at higher risk for adverse neonatal outcomes compared with patients without chorioamnionitis in the setting of PPROM.
研究胎膜早破（PPROM）合并绒毛膜羊膜炎的孕妇所分娩新生儿的结局。
在一所学术医疗中心，对妊娠24至34周诊断为PPROM的分娩病例进行回顾性队列研究。将诊断为临床绒毛膜羊膜炎的产妇与未诊断为此病的产妇进行比较。评估新生儿结局，包括阿氏评分、颅内出血（ICH）、败血症、肺炎、呼吸窘迫综合征（RDS）和坏死性小肠结肠炎（NEC）。使用卡方检验比较二分结局。进行多变量回归分析以控制潜在的混杂变量。
在1153例诊断为PPROM的患者中，29.0%在分娩前被诊断为绒毛膜羊膜炎。PPROM合并绒毛膜羊膜炎的母亲所分娩的新生儿，5分钟阿氏评分低、RDS、NEC、ICH和肺炎的发生率较高（34.8%），而未合并绒毛膜羊膜炎的母亲所分娩的新生儿发生率为22.9%（p<0.001）。
与PPROM未合并绒毛膜羊膜炎的患者相比，PPROM合并绒毛膜羊膜炎的患者出现不良新生儿结局的风险更高。
Zotero 插件