Yamaguchi M
Department of Orthopaedic Surgery, Faculty of Medicine, Kagoshima University, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1991 Aug;65(8):527-35.
HLA typing was carried out in 27 families with cases of ossification of the posterior longitudinal ligament (OPLL) in the cervical spine, with haplotype analysis for genetic factors. The results showed a significantly higher incidence of rare haplotypes in probands than in the general Japanese population, suggesting that certain genes linked to HLA are responsible for OPLL. On examination of the distribution of HLA haplotypes in families with members suffering from cervical OPLL, no evidence of OPLL was found in members with only one haplotype in common with the proband. In 9 of 15 siblings with two haplotypes in common, however, OPLL was observed. Further analysis of HLA haplotyping may contribute to the elucidation of the genetic determinants of OPLL linked to two HLA haplotypes, probably based on multifactorial inheritance.
对27个患有颈椎后纵韧带骨化症（OPLL）的家庭进行了HLA分型，并对遗传因素进行了单倍型分析。结果显示，先证者中罕见单倍型的发生率显著高于一般日本人群，这表明与HLA相关的某些基因与OPLL有关。在对患有颈椎OPLL的家庭成员的HLA单倍型分布进行检查时，发现与先证者仅有一个共同单倍型的成员中没有OPLL的迹象。然而，在15个有两个共同单倍型的兄弟姐妹中，有9个观察到了OPLL。HLA单倍型的进一步分析可能有助于阐明与两个HLA单倍型相关的OPLL的遗传决定因素，这可能基于多因素遗传。
