Gu Jia-Li, Wu Tao, Tong Hong-Fei, Sheng Li-Juan, Hu Li-Ying, Xu Yang, Fu Zheng-Wei
College of Jian Xing, Zhejiang University of Technology, Hangzhou 310032, China.
Sheng Li Ke Xue Jin Zhan. 2009 Apr;40(2):123-8.
It is well known that almost all organisms ranging from single cell creatures to human beings exhibit circadian rhythms in physiology and behavior under the control of the internal circadian clock. The internal circadian clock is composed of a master clock which is localized in the suprachiasmatic nucleus and the peripheral clocks located in peripheral tissues such as the liver and heart. Along with aging, the circadian rhythm alters in many aspects, including the amplitude, free-running period and the expression phase. On the other hand, the circadian clock also influences the process of aging. The disorganized circadian rhythm accelerates the aging process. This article briefly reviews the recent progress in the interactions between the circadian clock and aging, and provides evidence to further understand the mechanism of aging and the impact of aging on the organisms.
众所周知，几乎所有生物，从单细胞生物到人类，在内部生物钟的控制下，其生理和行为都会表现出昼夜节律。内部生物钟由位于视交叉上核的主时钟和位于肝脏、心脏等外周组织的外周时钟组成。随着衰老，昼夜节律在许多方面发生改变，包括振幅、自由运行周期和表达相位。另一方面，生物钟也影响衰老过程。紊乱的昼夜节律会加速衰老进程。本文简要综述了生物钟与衰老相互作用的最新进展，并提供证据以进一步了解衰老机制以及衰老对生物体的影响。
