Hurst Jillian H, Hooks Shelley B
Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602, USA.
Biochem Pharmacol. 2009 Nov 15;78(10):1289-97. doi: 10.1016/j.bcp.2009.06.028. Epub 2009 Jun 25.
The regulator of G-protein signaling (RGS) family is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). In recent years, GPCRs have been linked to the initiation and progression of multiple cancers; thus, regulators of GPCR signaling are also likely to be important to the pathophysiology of cancer. This review highlights recent studies detailing changes in RGS transcript expression during oncogenesis, single nucleotide polymorphisms in RGS proteins linked to lung and bladder cancers, and specific roles for RGS proteins in multiple cancer types.
G蛋白信号调节因子（RGS）家族是一类多样的多功能蛋白质，可调节G蛋白偶联受体（GPCR）下游的细胞信号转导事件。近年来，GPCR与多种癌症的发生和发展有关；因此，GPCR信号调节因子可能对癌症的病理生理学也很重要。本综述重点介绍了最近的研究，这些研究详细阐述了肿瘤发生过程中RGS转录本表达的变化、与肺癌和膀胱癌相关的RGS蛋白单核苷酸多态性，以及RGS蛋白在多种癌症类型中的具体作用。
