Dixit R P, Puthli S P
Drug Delivery Division, Panacea Biotec Ltd., Samarpan complex, Chakala, Andheri (East), Mumbai-400 099, Maharashtra, India.
J Control Release. 2009 Oct 15;139(2):94-107. doi: 10.1016/j.jconrel.2009.06.014. Epub 2009 Jun 24.
Over the recent past, many of the research groups are focusing their research on this technology. Amongst the plethora of avenues explored for rapid drug releasing products, Oral Strip Technology (OST) is gaining much attention. The advantages of OST are the administration to pediatric and geriatric patient population where the difficulty of swallowing larger oral dosage forms is eliminated. This technology has been used for local action, rapid release products and for buccoadhesive systems that are retained for longer period in the oral cavity to release drug in controlled fashion. OST offers an alternate platform for molecules that undergo first pass metabolism and for delivery of peptides. The review article is an overview of OST encompassing materials used in OST, critical manufacturing aspects, applications, commercial technologies and future business prospects of this technology.
近年来，许多研究团队都将研究重点集中在这项技术上。在探索快速释药产品的众多途径中，口腔条带技术（OST）备受关注。OST的优势在于可用于儿科和老年患者群体，消除了吞咽较大口服剂型的困难。这项技术已用于局部作用、快速释药产品以及口腔粘附系统，这些系统可在口腔中保留较长时间以可控方式释放药物。OST为经历首过代谢的分子和肽类递送提供了一个替代平台。这篇综述文章概述了OST，包括OST中使用的材料、关键制造方面、应用、商业技术以及该技术的未来商业前景。
