Scholz Oliver A, Wolff Andy, Schumacher Axel, Giannola Libero I, Campisi Giuseppina, Ciach Tomasz, Velten Thomas
Fraunhofer-Institut Biomedizinische Technik, St. Ingbert, Germany.
Drug Discov Today. 2008 Mar;13(5-6):247-53. doi: 10.1016/j.drudis.2007.10.018. Epub 2007 Dec 11.
Dental drug delivery systems have been used for a long time, in particular for the local therapy of diseases affecting the oral cavity. Research today concentrates on the design of formulations to increase their retention time. Even today, however, prosthetic devices incorporating drug delivery are rarely used. Mainly, they are focused on prophylaxis and the release of antibacterial agents. However, as buccal delivery, because of its undeniable advantages, has become popular for systemic drug delivery, and prolonged well-controlled release has been identified as beneficial, especially for chronic diseases, a new class of delivery systems is evolving: highly miniaturized computerized delivery systems, integrated into a dental appliance. Dental delivery systems today are used in two ways: the main application is the local treatment of diseases affecting the oral cavity itself like periodontitis or fungal infections. The second is for systemic drug delivery.
牙科给药系统已经使用了很长时间，特别是用于口腔疾病的局部治疗。如今的研究集中在设计制剂以延长其保留时间。然而，即使在今天，包含给药功能的修复装置也很少被使用。主要来说，它们专注于预防和抗菌剂的释放。然而，由于颊部给药因其不可否认的优势已在全身给药中变得流行，并且已确定延长的可控释放是有益的，特别是对于慢性疾病，一类新的给药系统正在发展：高度小型化的计算机化给药系统，集成到牙科器具中。如今牙科给药系统有两种使用方式：主要应用是局部治疗影响口腔本身的疾病，如牙周炎或真菌感染。第二种是用于全身给药。
