Department of Health Policy and Management, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205-7199, United States.
Addict Behav. 2009 Nov;34(11):959-64. doi: 10.1016/j.addbeh.2009.06.002. Epub 2009 Jun 6.
The primary objective of this study was to investigate whether drug use severity is associated with physical health-related quality of life (HRQL) over time. Data are from a longitudinal, multi-state, natural history community study of users of cocaine and/or methamphetamine who were interviewed at 6-month intervals over 2 years with a 79% follow-up participation rate. Physical HRQL was assessed with the physical component summary (PCS) of the SF-8 Health Survey and drug, alcohol, and psychiatric severity were all assessed with the Addiction Severity Index (ASI). Random coefficient regression analyses were conducted to test for longitudinal associations between the independent variables and SF-8 PCS scores. Reductions in drug use severity over time were accompanied by only minor improvements in SF-8 PCS scores, underscoring the potential long-term harm of illicit drug use on physical health. Greater psychiatric severity was strongly associated with lower SF-8 PCS scores, suggesting that clinical attention to mental health issues could potentially lead to improvements in perceived physical health as well as among stimulant users.
这项研究的主要目的是探究药物使用严重程度是否与身体健康相关的生活质量（HRQL）随时间推移而相关。数据来自于一项对可卡因和/或甲基苯丙胺使用者进行的纵向、多状态、自然史社区研究，这些参与者在两年内每隔 6 个月接受一次访谈，随访参与率为 79%。身体健康相关的生活质量使用 SF-8 健康调查的生理成分综合评分（PCS）进行评估，而药物、酒精和精神疾病严重程度则均使用成瘾严重程度指数（ASI）进行评估。采用随机系数回归分析来检验自变量与 SF-8 PCS 评分之间的纵向关联。随着时间的推移，药物使用严重程度的降低仅伴随着 SF-8 PCS 评分的轻微改善，这突显了非法药物使用对身体健康可能带来的长期危害。更严重的精神疾病与更低的 SF-8 PCS 评分密切相关，这表明对心理健康问题的临床关注可能会潜在地改善感知到的身体健康状况，这一结果也适用于兴奋剂使用者。
