Division of General Internal Medicine, Department of Medicine, University of Colorado Denver, Denver, CO, USA.
J Gen Intern Med. 2009 Sep;24(9):1073-9. doi: 10.1007/s11606-009-1042-5. Epub 2009 Jun 27.
This review examines the results of randomized controlled trials in which behavioral weight loss interventions, used alone or with pharmacotherapy, were provided in primary care settings.
Literature search of MEDLINE, PubMed, Cochrane Systematic Reviews, CINAHL, and EMBASE (1950-present). Inclusion criteria for studies were: (1) randomized trial, (2) obesity intervention in US adults, and (3) conducted in primary care or explicitly intended to model a primary care setting.
Both authors reviewed each study to extract treatment modality, provider, setting, weight change, and attrition. The CONSORT criteria were used to assess study quality. Due to the small number and heterogeneity of studies, results were summarized but not pooled quantitatively.
Ten trials met the inclusion criteria. Studies were classified as: (1) PCP counseling alone, (2) PCP counseling + pharmacotherapy, and (3) "collaborative" obesity care (treatment delivered by a non-physician provider). Weight losses in the active treatment arms of these categories of studies ranged from 0.1 to 2.3 kg, 1.7 to 7.5 kg, and 0.4 to 7.7 kg, respectively. Most studies provided low- or moderate-intensity counseling, as defined by the US Preventive Services Task Force.
Current evidence does not support the use of low- to moderate-intensity physician counseling for obesity, by itself, to achieve clinically meaningful weight loss. PCP counseling plus pharmacotherapy, or intensive counseling (from a dietitian or nurse) plus meal replacements may help patients achieve this goal. Further research is needed on different models of managing obesity in primary care practice.
本综述考察了在初级保健环境中单独使用或联合药物治疗提供行为减肥干预的随机对照试验结果。
对 MEDLINE、PubMed、Cochrane 系统评价、CINAHL 和 EMBASE(1950 年至今)进行文献检索。纳入研究的标准为:(1)随机试验;(2)美国成年人肥胖干预;(3)在初级保健中进行或明确旨在模拟初级保健环境。
两位作者均对每项研究进行了回顾,以提取治疗方式、提供者、环境、体重变化和脱落率。采用 CONSORT 标准评估研究质量。由于研究数量少且存在异质性,因此仅对结果进行了总结,而未进行定量汇总。
符合纳入标准的研究有 10 项。这些研究分为:(1)初级保健医生单独咨询;(2)初级保健医生咨询+药物治疗;(3)“协作”肥胖护理(由非医师提供者提供治疗)。这些研究类别的积极治疗组的体重减轻幅度分别为 0.1 至 2.3kg、1.7 至 7.5kg 和 0.4 至 7.7kg。大多数研究提供了美国预防服务工作组定义的低或中强度咨询。
目前的证据不支持单独使用低到中等强度的医生咨询来实现肥胖的临床意义上的减肥。初级保健医生咨询+药物治疗,或强化咨询(营养师或护士)+代餐可能有助于患者实现这一目标。需要进一步研究初级保健实践中不同的肥胖管理模式。