中国人群中维生素D受体基因多态性与冠状动脉疾病无关联。
No association between vitamin D receptor polymorphisms and coronary artery disease in a Chinese population.
作者信息
Pan Xin-Min, Li Dong-Ri, Yang Lan, Wang En-Yin, Chen Tian-Yi, Liu Ya-Ju, Liu Min, Liao Zhi-Gang
机构信息
Department of Forensic Pathology, West China School of Preclinical and Forensic Medicine, Sichuan University , Chengdu, Peoples' Republic of China .
出版信息
DNA Cell Biol. 2009 Oct;28(10):521-5. doi: 10.1089/dna.2009.0908.
The clinical features suggest that genetic factors may have a strong influence on susceptibility to coronary artery disease (CAD). The aim of this study was to investigate the association between FokI (rs2228570) and BsmI (rs1544410) of the vitamin D receptor (VDR) gene polymorphisms and patients with CAD in a Chinese population. One hundred and fifty-two CAD patients and 212 healthy controls were genotyped for the FokI and BsmI polymorphisms in VDR gene using polymerase chain reaction-restriction fragment length polymorphism. No significant differences were observed in the genotype and allele frequencies of the FokI and BsmI polymorphisms between the cases and controls (For FokI: odds ratio = 1.11, 95% confidence interval 0.83-1.50; for BsmI: odds ratio = 0.74, 95% confidence interval 0.44-1.23). There was no significant difference in the genotype distribution or the allele frequencies of VDR FokI and BsmI between two groups in a Chinese population.
临床特征表明，遗传因素可能对冠状动脉疾病（CAD）的易感性有很大影响。本研究的目的是调查中国人群中维生素D受体（VDR）基因多态性的FokI（rs2228570）和BsmI（rs1544410）与CAD患者之间的关联。采用聚合酶链反应-限制性片段长度多态性方法，对152例CAD患者和212例健康对照者的VDR基因FokI和BsmI多态性进行基因分型。病例组和对照组之间FokI和BsmI多态性的基因型和等位基因频率无显著差异（FokI：比值比=1.11，95%置信区间0.83-1.50；BsmI：比值比=0.74，95%置信区间0.44-1.23）。中国人群两组之间VDR FokI和BsmI的基因型分布或等位基因频率无显著差异。
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