维生素 D 缺乏和维生素 D 受体基因变异与沙特 2 型糖尿病患者冠心病的关系。
Association of Vitamin D Deficiency and Vitamin D Receptor Genetic Variants With Coronary Artery Disease in Type 2 Diabetic Saudi Patients.
机构信息
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif, Kingdom of Saudi Arabia.
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif, Kingdom of Saudi Arabia;
出版信息
In Vivo. 2022 May-Jun;36(3):1444-1452. doi: 10.21873/invivo.12850.
BACKGROUND/AIM: Vitamin D deficiency accelerates the onset of type 2 diabetes mellitus (T2DM). Polymorphisms in the vitamin D receptor (VDR) have been linked to coronary artery disease (CAD). This study aimed to evaluate the association of vitamin D deficiency and VDR polymorphism with CAD in T2DM.
PATIENTS AND METHODS
A total of 150 adult male and female subjects, aged from 40 to 60 years, were divided into three groups, each with 50 subjects; control group, T2DM, and T2DM with CAD. Fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), HDL-C, LDL-C, glycosylated hemoglobin (HbA1c), and 25-hydroxyvitamin D (25-OH D) were assessed. VDR genotypes (BsmI, Taq1 and FOK1) were investigated by polymerase chain reaction fragment length polymorphism.
RESULTS
There was a significant negative correlation between serum 25-OH D and FBG, TC, TG, and LDL-C levels, and a positive correlation with HDL-C levels in all diabetic patient groups. The risk of CAD was markedly higher in the group of T2DM with CAD in comparison to the control (p<0.0001) and the T2DM group. Regarding Taq1, there was also a significantly higher risk of CAD in Tt+tt genotypes and t allele in the T2DM with CAD group compared to control (p<0.001, 0.031 respectively). In addition, 25-OH D concentrations and the prevalence of VDR polymorphisms (BsmI, Taq1) were correlated with the risk of CAD.
CONCLUSION
Deficiency of vitamin D and the prevalence of VDR polymorphisms (BsmI, Taq1) can serve as important markers for CAD.
背景/目的：维生素 D 缺乏会加速 2 型糖尿病（T2DM）的发生。维生素 D 受体（VDR）的多态性与冠状动脉疾病（CAD）有关。本研究旨在评估维生素 D 缺乏和 VDR 多态性与 T2DM 合并 CAD 的相关性。
方法
共纳入 150 名年龄在 40 至 60 岁之间的成年男性和女性，分为三组，每组 50 人；对照组、T2DM 组和 T2DM 合并 CAD 组。检测空腹血糖（FBG）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、糖化血红蛋白（HbA1c）和 25-羟维生素 D（25-OH D）。采用聚合酶链反应片段长度多态性检测 VDR 基因型（BsmI、Taq1 和 FOK1）。
结果
所有糖尿病患者组中，血清 25-OH D 与 FBG、TC、TG 和 LDL-C 水平呈显著负相关，与 HDL-C 水平呈显著正相关。与对照组（p<0.0001）和 T2DM 组相比，T2DM 合并 CAD 组发生 CAD 的风险明显更高。Taq1 方面，与对照组相比，T2DM 合并 CAD 组中 Tt+tt 基因型和 t 等位基因发生 CAD 的风险显著更高（p<0.001、0.031）。此外，25-OH D 浓度和 VDR 多态性（BsmI、Taq1）的流行率与 CAD 风险相关。
结论
维生素 D 缺乏和 VDR 多态性（BsmI、Taq1）可作为 CAD 的重要标志物。
Zotero 插件