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2
Mitochondrial Myopathy, Encephalopathy, Lactic acidosis and Stroke-Like Episodes Syndrome Presenting With Anton-Babinski Syndrome and Concurrent Occipital Lobe Seizures.线粒体肌病、脑病、乳酸性酸中毒和卒中样发作综合征伴安托万-巴宾斯基综合征及枕叶癫痫发作
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The Relationship Between Vitamin D Deficiency and Glycated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus.2型糖尿病患者维生素D缺乏与糖化血红蛋白水平的关系
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Diminished 25-OH vitamin D levels and vitamin D receptor variants are associated with susceptibility to type 2 diabetes with coronary artery diseases.25-OH 维生素 D 水平降低和维生素 D 受体变异与 2 型糖尿病合并冠心病的易感性相关。
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10
Vitamin D receptor gene polymorphisms as a risk factor for obesity in Saudi men.维生素D受体基因多态性作为沙特男性肥胖的一个风险因素。
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维生素 D 缺乏和维生素 D 受体基因变异与沙特 2 型糖尿病患者冠心病的关系。

Association of Vitamin D Deficiency and Vitamin D Receptor Genetic Variants With Coronary Artery Disease in Type 2 Diabetic Saudi Patients.

机构信息

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif, Kingdom of Saudi Arabia.

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif, Kingdom of Saudi Arabia;

出版信息

In Vivo. 2022 May-Jun;36(3):1444-1452. doi: 10.21873/invivo.12850.

DOI:10.21873/invivo.12850
PMID:35478145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9087110/
Abstract

BACKGROUND/AIM: Vitamin D deficiency accelerates the onset of type 2 diabetes mellitus (T2DM). Polymorphisms in the vitamin D receptor (VDR) have been linked to coronary artery disease (CAD). This study aimed to evaluate the association of vitamin D deficiency and VDR polymorphism with CAD in T2DM.

PATIENTS AND METHODS

A total of 150 adult male and female subjects, aged from 40 to 60 years, were divided into three groups, each with 50 subjects; control group, T2DM, and T2DM with CAD. Fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), HDL-C, LDL-C, glycosylated hemoglobin (HbA1c), and 25-hydroxyvitamin D (25-OH D) were assessed. VDR genotypes (BsmI, Taq1 and FOK1) were investigated by polymerase chain reaction fragment length polymorphism.

RESULTS

There was a significant negative correlation between serum 25-OH D and FBG, TC, TG, and LDL-C levels, and a positive correlation with HDL-C levels in all diabetic patient groups. The risk of CAD was markedly higher in the group of T2DM with CAD in comparison to the control (p<0.0001) and the T2DM group. Regarding Taq1, there was also a significantly higher risk of CAD in Tt+tt genotypes and t allele in the T2DM with CAD group compared to control (p<0.001, 0.031 respectively). In addition, 25-OH D concentrations and the prevalence of VDR polymorphisms (BsmI, Taq1) were correlated with the risk of CAD.

CONCLUSION

Deficiency of vitamin D and the prevalence of VDR polymorphisms (BsmI, Taq1) can serve as important markers for CAD.

摘要

背景/目的：维生素 D 缺乏会加速 2 型糖尿病（T2DM）的发生。维生素 D 受体（VDR）的多态性与冠状动脉疾病（CAD）有关。本研究旨在评估维生素 D 缺乏和 VDR 多态性与 T2DM 合并 CAD 的相关性。

方法

共纳入 150 名年龄在 40 至 60 岁之间的成年男性和女性，分为三组，每组 50 人；对照组、T2DM 组和 T2DM 合并 CAD 组。检测空腹血糖（FBG）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、糖化血红蛋白（HbA1c）和 25-羟维生素 D（25-OH D）。采用聚合酶链反应片段长度多态性检测 VDR 基因型（BsmI、Taq1 和 FOK1）。

结果

所有糖尿病患者组中，血清 25-OH D 与 FBG、TC、TG 和 LDL-C 水平呈显著负相关，与 HDL-C 水平呈显著正相关。与对照组（p<0.0001）和 T2DM 组相比，T2DM 合并 CAD 组发生 CAD 的风险明显更高。Taq1 方面，与对照组相比，T2DM 合并 CAD 组中 Tt+tt 基因型和 t 等位基因发生 CAD 的风险显著更高（p<0.001、0.031）。此外，25-OH D 浓度和 VDR 多态性（BsmI、Taq1）的流行率与 CAD 风险相关。

结论

维生素 D 缺乏和 VDR 多态性（BsmI、Taq1）可作为 CAD 的重要标志物。