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研究维生素 D 受体基因多态性在冠心病心肌梗死患者队列中的作用。

Study of vitamin D receptor gene polymorphisms in a cohort of myocardial infarction patients with coronary artery disease.

机构信息

Department of Medical Rehabilitation, Medical Faculty, University of Rijeka, B. Branchetta 20, 51000, Rijeka, Croatia.

Division of Cardiology, Hospital for Medical Rehabilitation of the Heart and Lung Diseases and Rheumatism "Thalassotherapia Opatija", M. Tita 188, 51410, Opatija, Croatia.

出版信息

BMC Cardiovasc Disord. 2021 Apr 16;21(1):188. doi: 10.1186/s12872-021-01959-x.

DOI:10.1186/s12872-021-01959-x
PMID:33863283
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8052753/
Abstract

BACKGROUND

Vitamin D deficiency is associated with cardiovascular diseases, including coronary artery diseases (CAD). As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Therefore, the objective of this study was to analyze three well-studied VDR gene polymorphisms-Fok1 (rs2228570), BsmI (rs1544410) and Taq1 (rs731236)-in a cohort of CAD patients after acute myocardial infarction.

METHODS

In the presented cross-sectional study, 155 participants with CAD after acute myocardial infarction and 104 participants in a control group without CAD were enrolled. The participants in both groups were Caucasians of European origin. The genotyping of VDR polymorphisms rs2228570, rs1544410 and rs731236 was assessed by RT-PCR.

RESULTS

The results show an association between the T/T genotype of the BsmI (rs1544410) and the G/G genotype of the Taq1 (rs731236) VDR polymorphism and CAD patients after acute myocardial infarction. There was no association between the Fok1 (rs2228570) VDR polymorphism and CAD patients after acute myocardial infarction.

CONCLUSION

The presented results suggest a potential association of the BsmI (rs1544410) and Taq1 (rs731236) VDR polymorphisms with CAD patients after myocardial infarction.

摘要

背景

维生素 D 缺乏与心血管疾病有关，包括冠心病（CAD）。由于维生素 D 通过其维生素 D 受体（VDR）发挥生物学功能，VDR 基因多态性可能影响 VDR 功能和维生素 D 活性。因此，本研究旨在分析 CAD 患者急性心肌梗死后三种研究充分的 VDR 基因多态性-Fok1（rs2228570）、BsmI（rs1544410）和 Taq1（rs731236）。

方法

在这项横断面研究中，纳入了 155 名 CAD 患者（急性心肌梗死后）和 104 名 CAD 对照组患者。两组参与者均为欧洲裔白种人。通过 RT-PCR 检测 VDR 多态性 rs2228570、rs1544410 和 rs731236 的基因分型。

结果

结果显示，BsmI（rs1544410）T/T 基因型和 Taq1（rs731236）G/G 基因型与急性心肌梗死后 CAD 患者之间存在关联。Fok1（rs2228570）VDR 多态性与急性心肌梗死后 CAD 患者之间无关联。

结论

本研究结果提示 BsmI（rs1544410）和 Taq1（rs731236）VDR 多态性与急性心肌梗死后 CAD 患者存在潜在关联。

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Vitamin D-binding protein and vitamin D receptor genotypes and 25-hydroxyvitamin D levels are associated with development of aortic and mitral valve calcification and coronary artery diseases.维生素 D 结合蛋白和维生素 D 受体基因型与 25-羟维生素 D 水平与主动脉瓣和二尖瓣钙化及冠状动脉疾病的发生有关。
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Mendelian Randomization Studies Do Not Support a Role for Vitamin D in Coronary Artery Disease.孟德尔随机化研究不支持维生素D在冠状动脉疾病中起作用。
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