Institute of Neurology CCS, Belgrade, Serbia.
Epilepsia. 2010 Jan;51(1):57-61. doi: 10.1111/j.1528-1167.2009.02188.x. Epub 2009 Jun 26.
To determine long-term survival in patients with status epilepticus (SE).
We prospectively followed patients admitted for the first (69.6%) or recursive episode of SE between January 1, 1989 and December 31, 1997 at the Institute of Neurology, Belgrade, Serbia, until death or study termination (December 31, 2006). Data were obtained for cause of death; etiology of SE-acute symptomatic (AS), progressive symptomatic (PS), remote symptomatic (RS), and idiopathic/cryptogenic (I/C); presence of epilepsy; and reoccurrence of SE. Standardized mortality rate (SMR), survival, and regression analysis were used.
A total of 120 of 750 patients with an episode of SE (15.9%) died in the 30-day period following SE. Data for 207 of 630 (32.8%) surviving patients (35.7% with initial SE) were available at the end of follow-up [median 12 years; 95% confidence interval (CI) 11.1-12.8]. SMR was significantly increased (SMR = 1.81; 95% CI 1.32-2.41). There were 46 deaths (22.2%): 15 of 65 in the AS, 20 of 29 in the PS, 6 of 29 in the RS, and 5 of 75 in the I/C groups. Five-year survival rate was lowest in the PS (45%) compared to AS (91%), RS (87%), and I/C (99%) groups. The following characteristics increased long-term risk for mortality: older age [Exp(B) 1.05, 95% CI 1.029-1.072], PS and AS etiology [Exp(B) 15.6, 95% CI 5.8-41.6; 3.3, 95% CI 1.2-9.1], presence of epilepsy [Exp(B) 2.3, 95% CI 1.2-4.3], and initial SE [Exp(B) 2.4, 95% CI 1.4-4.4].
Approximately one of five patients die within 12 years after an episode of SE. Symptomatic SE (PS and AS), initial SE, age, and presence of epilepsy are associated with long-term increased risk of death.
确定癫痫持续状态（SE）患者的长期生存情况。
我们前瞻性地随访了 1989 年 1 月 1 日至 1997 年 12 月 31 日期间在塞尔维亚贝尔格莱德神经病学研究所因首次（69.6%）或递归性 SE 发作而入院的患者[630 例中的 207 例（初始 SE 为 35.7%）在研究结束时（2006 年 12 月 31 日）]仍存活。获得了死亡原因；SE 的病因——急性症状性（AS）、进行性症状性（PS）、远隔症状性（RS）和特发性/隐源性（I/C）；癫痫存在情况；以及 SE 的再发情况。使用标准化死亡率（SMR）、生存和回归分析。
在 SE 后 30 天内，750 例 SE 发作患者中有 120 例（15.9%）死亡。在随访结束时[中位数 12 年；95%置信区间（CI）11.1-12.8]，有 630 例存活患者（35.7%为初始 SE）的 207 例数据可用。SMR 显著升高（SMR=1.81；95%CI 1.32-2.41）。共有 46 人死亡（22.2%）：AS 组 15 人，PS 组 20 人，RS 组 6 人，I/C 组 5 人。PS（45%）组的 5 年生存率明显低于 AS（91%）、RS（87%）和 I/C（99%）组。以下特征增加了长期死亡风险：年龄较大[Exp（B）1.05，95%CI 1.029-1.072]，PS 和 AS 病因[Exp（B）15.6，95%CI 5.8-41.6；3.3，95%CI 1.2-9.1]，癫痫存在[Exp（B）2.3，95%CI 1.2-4.3]，以及初始 SE[Exp（B）2.4，95%CI 1.4-4.4]。
大约五分之一的患者在 SE 发作后 12 年内死亡。症状性 SE（PS 和 AS）、初始 SE、年龄和癫痫存在与长期死亡风险增加相关。
