Laboratory of Toxicology, Faculty of Marine and Environmental Sciences, University of Cádiz, Avda. República Saharaui s/n Apdo, 40. Puerto Real 11510, Cádiz, Spain.
Environ Toxicol. 2010 Dec;25(6):601-7. doi: 10.1002/tox.20521.
This study was conducted to examine the acute toxicity of the organophosphorus pesticide (OP) parathion on embryos and yolk-sac larvae of gilthead seabream (Sparus aurata), and to investigate the effects of this compound on cholinesterase and carboxylesterase activity of seabream larvae in the phase of endogenous feeding. The 72-h LC50 for yolk-sac larvae (0.523 mg L⁻¹) was about two-fold lower than the 48-h LC50 for embryos (1.005 mg L⁻¹). Parathion significantly inhibited the activity of ChE and CaE activity in yolk sac larvae but there were not significant differences in the sensitivity of both esterases to parathion as inferred by their 72-h IC50 values. Larvae exposed to parathion for 72 h showed a 70% inhibition of the whole body acetylcholinesterase at approximately the LC50.
本研究旨在检测有机磷农药对虾虎鱼胚胎和卵黄囊幼体的急性毒性，并研究该化合物对内源性摄食阶段虾虎鱼幼体胆碱酯酶和羧酸酯酶活性的影响。卵黄囊幼体的 72 小时 LC50（0.523mg/L）约为胚胎 48 小时 LC50（1.005mg/L）的两倍。对虾虎鱼卵黄囊幼体的研究发现，对硫磷显著抑制了 ChE 和 CaE 活性，但根据其 72 小时 IC50 值，两种酯酶对硫磷的敏感性没有显著差异。暴露于对硫磷 72 小时的幼虫，其全身体乙酰胆碱酯酶活性约抑制 70%，接近 LC50 值。
