Tobback E, Decostere A, Hermans K, Ryckaert J, Duchateau L, Haesebrouck F, Chiers K
Department of Pathology, Bacteriology and Avian Diseases, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Dis Aquat Organ. 2009 Apr 27;84(3):219-28. doi: 10.3354/dao02057.
Yersinia ruckeri is the causative agent of enteric redmouth disease, which leads to significant losses in salmonid aquaculture worldwide. Despite the significance of the disease, little information is available on the pathogenesis. In this study, the portal of entry was investigated using a contact-exposure infection method in rainbow trout Oncorhynchus mykiss with 4 different Y. ruckeri strains. Bacteriological and histological examination revealed the presence of high numbers of bacteria in the gills immediately after infection resulting in a rapid spread of Y. ruckeri in the internal organs. However, only a virulent strain was able to survive and multiply in the host, causing septicaemia and death several days after infection. These findings indicate that gills may be an important site of entry and that Y. ruckeri virulence is related to immune evasion.
鲁氏耶尔森菌是肠道红嘴病的病原体，该病在全球鲑科鱼类养殖中造成重大损失。尽管该疾病具有重要性，但关于其发病机制的信息却很少。在本研究中，使用接触暴露感染方法，对4种不同鲁氏耶尔森菌菌株感染虹鳟（Oncorhynchus mykiss）的感染途径进行了研究。细菌学和组织学检查显示，感染后鳃中立即存在大量细菌，导致鲁氏耶尔森菌在内脏中迅速传播。然而，只有一株强毒株能够在宿主体内存活并繁殖，在感染几天后引起败血症和死亡。这些发现表明，鳃可能是一个重要的感染部位，并且鲁氏耶尔森菌的毒力与免疫逃避有关。
