通过糖基化吲哚咔唑的组合生物合成产生强效和选择性激酶抑制剂。
Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles.
作者信息
Sánchez César, Salas Aaroa P, Braña Alfredo F, Palomino Martina, Pineda-Lucena Antonio, Carbajo Rodrigo J, Méndez Carmen, Moris Francisco, Salas José A
机构信息
Department Biología Funcional & Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain.
出版信息
Chem Commun (Camb). 2009 Jul 21(27):4118-20. doi: 10.1039/b905068j. Epub 2009 May 27.
DOI:10.1039/b905068j
PMID:19568652
Abstract
We report the generation of novel glycosylated indolocarbazoles by combinatorial biosynthesis, and the identification of two novel potent and selective compounds inhibitors of JAK2 and Ikkb kinases.
摘要
我们报告了通过组合生物合成产生新型糖基化吲哚咔唑，以及鉴定出两种新型的JAK2和Ikkb激酶强效选择性化合物抑制剂。
Zotero 插件