Tworowska-Bardzińska Urszula, Kubicka Eliza, Slezak Ryszard, Mielcarek Monika, Bednarek-Tupikowska Grazyna, Bolanowski Marek, Milewicz Andrzej
Department of Endocrinology, Diabetology, and Isotope Therapy, Medical University of Wrocław, Poland.
Endokrynol Pol. 2009 May-Jun;60(3):172-9.
Homozygosity for interleukin-6 (IL-6) 174G_C promoter polymorphism has recently been associated with indices of metabolic syndrome; however, this problem has not been investigated in non-obese subjects. The aim of this study was to explore the relation between abdominal fat distribution and some inflammatory risk factors of atheromatosis and IL-6 174G_C gene polymorphism in non-obese healthy subjects.
Relationships were investigated between anthropometric variables, i.e. weight, height, BMI, waist circumference (WC), waist-to-hip ratio (WHR), body fat distribution (DXA), serum CRP and IL-6, insulin sensitivity/resistance indices, and IL-6 174G_C gene polymorphism, in healthy non-obese Polish subjects: 232 women (age 31.4 +/- 5.5 years) and 199 men (age 30.3 +/- 6.0 years).
The genetic study revealed that the CC genotype was observed in 15.56% of subjects, the CG genotype in 52.74%, and the GG genotype in 31.7%. IL-6 and CRP concentration did not differ among the genotypes. There were also no differences regarding BMI and WHR. The only differences among genotypes, observed only in men, were those concerning total fat (CC had higher fat content than CG and GG); the difference being statistically significant between CC and GG (p < 0.05), and gynoidal fat deposit (CC had higher gynoidal fat deposit than CG and GG); the difference being statistically significant between CC and GG (p < 0.025) and between CC and CG (p < 0.05). Biochemical parameters and insulin sensitivity did not differ among the genotypes.
These data show that IL-6 174G_C polymorphism is not associated with features describing metabolic syndrome in nonobese healthy subjects.
白细胞介素-6（IL-6）174G_C启动子多态性的纯合性最近与代谢综合征指标相关；然而，该问题尚未在非肥胖受试者中进行研究。本研究的目的是探讨非肥胖健康受试者腹部脂肪分布与动脉粥样硬化的一些炎症风险因素及IL-6 174G_C基因多态性之间的关系。
在健康的非肥胖波兰受试者中，研究了人体测量变量（即体重、身高、体重指数、腰围、腰臀比、体脂分布（双能X线吸收法））、血清CRP和IL-6、胰岛素敏感性/抵抗指数与IL-6 174G_C基因多态性之间的关系，其中包括232名女性（年龄31.4±5.5岁）和199名男性（年龄30.3±6.0岁）。
基因研究显示，15.56%的受试者为CC基因型，52.74%为CG基因型，31.7%为GG基因型。各基因型之间的IL-6和CRP浓度无差异。BMI和腰臀比也无差异。仅在男性中观察到的各基因型之间的唯一差异是总脂肪方面（CC的脂肪含量高于CG和GG）；CC与GG之间差异具有统计学意义（p<0.05），以及女性型脂肪沉积方面（CC的女性型脂肪沉积高于CG和GG）；CC与GG之间差异具有统计学意义（p<0.025），CC与CG之间差异具有统计学意义（p<0.05）。各基因型之间的生化参数和胰岛素敏感性无差异。
这些数据表明，IL-6
